DMPK Scientist

We’re seeking a DMPK Scientist to join us in our mission to transform the discovery of therapeutics!

Our drug discovery and preclinical development team includes a cross-functional group of  scientists and drug developers with experience working on all common target classes and  therapeutic areas. The group is supported by more than 100 software developers and  engineers, as well as a large-scale compute infrastructure to apply our proprietary physics based drug design and optimization platform. Ten of the programs we’ve worked on have  progressed into preclinical development, with nine currently in clinical trials and one approved  by the FDA.  

Who will love this job: A DMPK analysis expert, who understands ADME principles and applications throughout drug development applications throughout drug discovery and development A scientist with a robust background in DMPK who has specialized in the use and application of any of the following:o In vitro/in vivo drug metabolism or transporter approaches to identify potential ADME liabilities and aid in compound optimizationo PK/PD and PBPK modeling approaches to optimize compound selection, dose optimization, and study design (this includes experience with commonly-used PK/PD software, such as Phoenix/Win Nonlin, SimCYP, Monolix, MATLAB Sim Biology, or other equivalent software)
A proven Principal Investigator and scientific strategist who’s self-driven and results-orientedA highly motivated, self-driven, and results-oriented data-analyzer An excellent communicator and presenter who can work both as a team player and a  project driver A flexible, curious scientist who’s excited about networking and building internal  and external relationships

What you will do:

Develop and drive DMPK and PK/PD strategy for drug discovery projects Represent the DMPK group on internal and intercompany project teams to help turn molecular modeling design ideas into druggable novel chemical entities Collaborate with internal and intercompany project team members and external CROs to  generate relevant data to enable knowledge and data integration Analyze and integrate in silico ADME predictive solutions, physicochemical, ADME, and  DMPK data to impact multiparameter optimization Author and/or review appropriate reports for regulatory submission of development drug  candidates and ensure the overall quality of the studies and interpretation (this entails supporting interactions with regulatory agencies)
Collaborate with scientific development team on establishment  of predictive computational ADME/DMPK models What you should have:
PhD in life sciences, chemical engineering, pharmacokinetics, pharmaceutical sciences,  or a related discipline with at least five years of experience working with DMPK in the  pharmaceutical industry or Master’s degree in life sciences, chemical engineering,  pharmacokinetics, pharmaceutical sciences, or a related discipline with at least ten years of experience working with DMPK in the pharmaceutical industry Prior experience independently representing DMPK on project teams

Payand perks:

Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, equity-based compensation, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have a company culture that is relaxed, but engaged, and over a month of paid vacation time.  

Our Office Management team also plans a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been included in Crain's New York Best Places to Work,…