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Scientist – Discovery Biology/T-cells
Job in
San Diego, San Diego County, California, 92189, USA
Listed on 2026-10-16
Listing for:
Dawar Consulting
Full Time
position Listed on 2026-10-16
Job specializations:
-
Research/Development
Research Scientist, Biotech Research, Biomedical Science
Job Description & How to Apply Below
San Diego, United States
Our client, a world leader in life sciences and biotechnology, islooking for a“Scientist – Discovery Biology/ T cells” based in San Diego, CA.
Job Duration:Long Term Contract(Possibility of Extension) Pay Rate: $49.20/hr on W2 Company Benefits:
- Medical, Paid Sick leave,401K
Join the Discovery Biology team to support a high-priority binder screening campaign for T-cell-based therapies. Characterize candidate binders(scFvs/VHHs) for potency, specificity, affinity, functionality, and safety through T-cell engineering and functional validation assays.
Key Responsibilities- Perform non-viral engineering of primary human T cells using mRNA or transposon-based DNA systems via electroporation/nucleofection; monitor cell viability,recovery, and synthetic receptor expression.
- Isolate, maintain,and expand primary T cells from PBMCs and Jurkat cell lines using aseptic techniques.
- Execute high-throughput binder screening and multi-color flow cytometry (FACS) toassess surface expression and phenotypic markers; analyze data using
FlowJo. - Conduct T-cell activation and functional assays, including cytotoxicity assays (Incu Cytelive-cell imaging/LDH release), cytokine profiling (ELISA/MSD/Luminex),and proliferation assays (CFSE).
- Record protocols,deviations, raw data, and experimental results accurately in an Electronic Lab Notebook (ELN) to support data integrity and regulatory filings.
- Support screening scale-up using liquid-handling robotics, as applicable.
- Bachelor's or Master's degree in Immunology, Molecular Biology, Bioengineering, or arelated biological science.
- Minimum 2 years ofhands-on wet-lab experience, preferably in an industry setting.
- Strong aseptic technique and experience isolating primary T cells from PBMCs.
- Mandatory expertise in flow cytometry acquisition and data analysis.
- Hands-on experience with non-viral T-cell transfection/electroporation ornucleofection.
- Experience with liquid-handling robotics and high-throughput screening workflows.
- Proficiency inFlowJo and functional T-cell assay techniques.
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