Scientist II - LNP Formulation

The Fountain Group is currently seeking a LNP Formulation Scientist for a prominent client of ours. This position is located in San Diego, CA. Details for the position are as follows:

Job Description:

• Formulate and optimize LNPs encapsulating nucleic acids, including mRNA, siRNA, or DNA.

• Execute Design of Experiments (DoE) screening campaigns to evaluate LNP compositions and processing parameters.

• Characterize LNPs and analyze, interpret, and present experimental results.

• Support early-stage formulation development, cryoprotection, scale-up, and stability studies as needed.

• Maintain detailed laboratory records and support routine lab operations, including inventory, ordering supplies, buffer preparation, and autoclaving.

• Collaborate with cross-functional teams to fulfill formulation requests.

Qualifications:

• Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related field with 5+ years of biopharma industry experience
  , or a Master's degree with 2+ years of industry experience
  .

• 2+ years of hands-on LNP formulation experience
  , including nucleic acid encapsulation.

• Experience with LNP characterization techniques, including:

  • Dynamic Light Scattering (DLS)

  • Zeta potential

  • Ribogreen assays

• High proficiency in Microsoft Excel.

• Strong data analysis, documentation, organizational, and communication skills.
• Demonstrated attention to detail and ability to generate reproducible experimental data.

• Experience preparing targeted LNPs, including mAb-, Fab-, scFv-, or VHH-coated LNPs.

• Experience with immune cell delivery.

• Familiarity with statistical and data analysis software such as JMP or Graph Pad Prism.

• Experience with DoE-based formulation screening.

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