Medicinal Chemistry Senior Principal Research Scientist

Job Description Vertex is seeking a Senior Principal Research Scientist, Medicinal Chemistry to provide scientific leadership in the design and optimization of small-molecule therapeutics across discovery programs. Leading from the lab, this role will play a critical part in advancing high-quality drug candidates from early discovery through candidate selection, while partnering across multidisciplinary teams to solve complex scientific challenges.

The ideal candidate is an accomplished medicinal chemist with deep expertise in small-molecule drug discovery, a strong record of scientific innovation, and demonstrated success in a fast-paced and matrixed research environment. This is an on-site role with approximately 75% of time being spent in the lab.

Key Responsibilities Lead medicinal chemistry strategy for small-molecule discovery programs aligned with portfolio and project objectives.

Design, prioritize, and guide synthesis of novel compounds to optimize potency, selectivity, pharmacokinetics, and develop ability.

Interpret and integrate SAR, structural biology, DMPK, pharmacology, and safety data to drive compound design and progression.

Partner closely with biology, DMPK, toxicology, and pharmaceutical sciences to advance program goals.

Provide technical and strategic leadership to internal and external chemistry resources.

Provide scientific leadership, mentorship, and development support to chemistry team members.

Communicate program strategy, data, risks, and recommendations to senior leadership and governance teams.

Support intellectual property strategy in partnership with internal stakeholders.

Knowledge and

Skills:

Medicinal chemistry

Organic synthesis

Small-molecule drug discovery

Lead optimizationSAR analysis

Compound design

Candidate selectionDMPK/ADME collaboration

Drug property optimization

Patent support

Education and Experience:

Ph.D. in Chemistry or related scientific discipline with 6+ years of relevant postdoctoral industry experience;
Master’s degree with 9+ years of relevant industry experience; or Bachelor’s degree with 11+ years of relevant industry experience.

Significant experience in medicinal chemistry and small-molecule drug discovery.

Demonstrated success advancing discovery programs through candidate selection.

Experience leading cross-functional and multidisciplinary teams including in matrixed settings.

Strong communication, strategic thinking, decision-making, prioritization, and problem-solving skills.#LI-KM1#LI-Onsite At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:$164,400 - $246,600

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.  From medical, dental and vision benefits to generous paid time off (including a week-long company…