Software Engineer - Instrument Software

Staff Software Engineer - Instrument Software

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What if the work you did every day could impact the lives of people you know? Or all of humanity?

At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life‑changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.

Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world‑changing projects, you will do more and become more than you ever thought possible.

We are seeking a Staff Software Engineer for our Hardware Integration and Frameworks (HWI) platform team. This role is critical to our instrument sequencing platforms, serving as the bridge between our firmware/hardware subsystems and the high‑level, user‑facing applications powering our DNA sequencing products. You will drive technical excellence in system architecture, mentor engineers, and ensure the HWI platform scales to meet product requirements across multiple product lines.

Technical Leadership

• Own the architectural design and evolution of the HWI software subsystem, ensuring scalability, reliability, and maintainability
• Drive subsystem‑level architecture decisions and contribute to product‑wide technical strategy
• Define and enforce engineering standards, best practices, design patterns for hardware/software integration
• Evaluate and introduce new technologies and tools to improve development efficiency

Software Development

• Design and develop critical HWI components using C#/.NET and Linux‑based systems
• Implement robust interfaces between Hardware Abstraction and Application Layers
• Optimize system performance and resource utilization
• Create comprehensive testing strategies including unit, automation, and hardware simulation

Problem Solving & Risk Management

• Independently investigate and resolve complex system‑level issues
• Proactively identify technical risks and develop mitigation strategies
  
  Debug complex timing, concurrency, and hardware interaction issues
• Perform root cause analysis and implement systemic improvements

Collaboration & Mentorship

• Partner with hardware, firmware, and software teams to define interfaces and integration strategies
• Mentor engineers in software design, debugging techniques, and best practices
• Build strong relationships across product development functions to align technical solutions with business objectives
• Communicate technical concepts effectively to both technical and non‑technical stakeholders
• Contribute to the long‑term product roadmap and help define departmental technical goals

Skills

• Strong proficiency in C# and .Net Core
• Experience with Linux environments
• Proven experience developing hardware abstraction layers and firmware/software integration
• Deep understanding of service‑oriented architecture, object‑oriented analysis and design, event‑driven design, and other architectural patterns
• Experience in REST API design
• Multi‑threading, synchronization, and concurrent programming

Nice to Have

• CI/CD pipeline design and implementation
• Static analysis tools and security scanning
• Performance profiling and optimization
• Proficiency with Atlassian tools like Jira and requirements management tools (like Jama)
• Basic proficiency in Typescript and Angular

Education & Experience

• Bachelor's degree in Computer Science, Software Engineering, Electrical Engineering, or related field
• 8+ years of professional software development experience

The estimated base salary range for the Staff Software Engineer - Instrument Software role based in the United States of America is: $152,600 - $228,800. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. Compensation decisions are dependent on several factors including, but not limited to, an individual’s qualifications, location where…