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Software Engineer, AI Engineer (Applied​/Software), Data Scientist

Job in San Diego, San Diego County, California, 92184, USA
Listing for: Illumina
Full Time position
Listed on 2026-10-17
Job specializations:
  • Software Development
    Software Engineer, AI Engineer (Applied/Software), Data Scientist, Machine Learning/ ML Engineer
Salary/Wage Range or Industry Benchmark: 155600 - 233400 USD Yearly USD 155600.00 233400.00 YEAR
Job Description & How to Apply Below
Position: Staff Software Engineer
What if the work you did every day could impact the lives of people you know? Or all of humanity?

At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.

Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

What if the work you did everyday could impact the lives of people you know? Or all of humanity?  At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.  

Working at Illumina means being part of something bigger than yourself. Every person, in every role, can make a difference. Surrounded by extraordinary people, inspiring leaders, and world-changing projects, you will do more and become more than you ever thought possible.

We are searching for a software engineer who is ready to join us in this important mission. Illumina’s Primary Analysis team specializes in designing algorithms and developing software to detect genomic data from signals contained within images.  Implementation challenges include managing parallel tasks, optimizing memory accesses, and improving the speed and accuracy of genomic base calling. We develop methods to address these challenges by focusing on high reliability, speed, and completeness of results.  

We are seeking an exceptional individual to join our team in developing analysis solutions for use by researchers and clinicians worldwide.

Responsibilities:

Define software architecture solutions for our high-performance signal processing pipelines

Design, develop, debug, and integrate C/C++ software on Linux for multi-threaded applications

Optimize and accelerate software executed on Illumina instruments

Closely interact with the bioinformatics team, instrument design team, test and quality teams

Collaborate in an agile environment to maintain high quality software against established processes

Maintain awareness of industry trends and evaluate applicability of new software and hardware technologies to platform development efforts

Provide technical leadership where needed

Requirements:

Extensive knowledge and experience with C/C++, Java or C#Experience in multi-threading, and memory management techniques

Proficient with tools for software debugging and troubleshooting (GDB, etc.)Proficient with tools for software performance analysis and optimization

Proficient with source control management repositories (such as GIT, SVN, etc.)Extensive experience writing high quality unit tests against mock objects

Good understanding of object-oriented analysis and design

Strong problem-solving skills

Desired:

Extensive knowledge and experience in developing software for real-time systems

Experience with image processing algorithms and techniques

Experience with time-series analysis and interpretation of temporal data

Experience with Python and Python visualization libraries

Be customer-focused, team-oriented, and motivated, taking ownership of assigned tasks

Have proven ability to self-manage, as well as manage interdisciplinary relationships

Have proven verbal and written communication skills

Education & Experience:

BS/MS in Computer Science, EE, Bioinformatics, or related field8+ years of professional software development experience#LI-HYBRIDThe estimated base salary range for the Staff Software Engineer role based in the United States of America is: $155,600 - $233,400. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. The range reflects long‑term growth in the role;

therefore, most candidates are hired between the minimum and middle of the range. Placement depends on experience, skills, location, and internal equity. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as…
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