Associate Scientist​/Scientist, In Vivo Pharmacology; industry

Associate Scientist/Scientist, In Vivo Pharmacology (industry experience required)

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Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life‑changing medicines for patients with the vision to become the industry‑leading G protein‑coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial‑scale drug discovery for the entire class of GPCRs.

Septerna has an emerging pipeline of GPCR‑targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date.

We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals;

and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground‑breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.

We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the front lines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease‑modifying therapeutics for patients in a fast‑paced environment.

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The Associate scientist/Scientist will primarily be responsible for the development and conduct of in‑vivo, ex‑vivo, as well as in‑vitro studies in in‑vivo Pharmacology to support the advancement of Septerna’s small molecule drug discovery pipeline. They will help develop preclinical models, generate robust data to support therapeutic development and contribute to the understanding of therapeutic mechanism of action. The successful candidate will add their passion, unique talents, and expertise to a dynamic team on the front lines of innovative therapeutic development.

The position is based in South San Francisco, CA. Title and compensation commensurate with experience.

• Perform surgical procedures in rodents
• Design and execute in‑vivo and in‑vitro studies in rodents
• Generate, analyze, document, and help interpret data to establish functional PK/PD relationships
• Contribute to the interpretation of experimental results in a broader biological and pharmacological context to progress our understanding of target biology and therapeutic hypothesis
• Help in authoring in‑vivo pharmacology study designs, protocols, and reports to support regulatory filings
• Follow all company policies/practices, and maintain accurate records and notebooks

• BSc or MSc in Pharmacology, Toxicology, or related biological science
• At least 10 (or 8 years with MSc) direct experience with generating complex surgical models in rodents in academia or the biotechnology and pharmaceutical industries
• Ability to collaborate in writing protocols and trouble‑shooting biological experiments
• Detail‑oriented and organized, with strong interpersonal skills for clear and effective communication
• Ability to proactively engage and collaborate with colleagues to integrate in‑vivo findings with in‑vitro pharmacology studies

• Experience working with rodent models of bone, kidney, and/or endocrine organs
• Previous work…