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Principal Scientist, Immunology

Job in San Francisco, San Francisco County, California, 94199, USA
Listing for: Biogen, Inc.
Full Time position
Listed on 2026-01-13
Job specializations:
  • IT/Tech
    Data Science Manager
  • Research/Development
Salary/Wage Range or Industry Benchmark: 150000 - 200000 USD Yearly USD 150000.00 200000.00 YEAR
Job Description & How to Apply Below
* ** Design and lead
** innovative in vitro and in vivo studies to uncover mechanisms driving inflammatory and autoimmune diseases.
* ** Discover and validate
** novel drug targets, biomarkers, and pathways critical to immune-mediated disorders.
* ** Deliver high-quality data
** to support lead optimization, biomarker development, and translational research for priority programs in our expanding Immunology pipeline.
* ** Analyze and interpret complex datasets**, ensuring scientific rigor, reproducibility, and adherence to regulatory and safety standards; communicate findings through internal presentations and external forums (conferences, publications).
* ** Collaborate across disciplines**—including pharmacology, synthetic medicine, protein engineering, and computational sciences—to advance target identification, drug discovery, and clinical development.
* ** Shape portfolio strategy
** by identifying gaps and opportunities for scientific innovation.
* ** Partner with business development and corporate strategy teams
** to evaluate the scientific merit of potential assets, collaborations, and licensing opportunities.
* ** Contribute to due diligence efforts**, including mechanistic evaluations, protocol reviews, external data assessments, and intellectual property analysis.
* ** Champion scientific excellence and innovation
** by staying current with emerging research and technologies in immunology and inflammation.
*
* Qualifications:

*** PhD in Immunology, Cellular and Molecular Biology, or a related scientific field with 5+ years of industry experience, preferably in inflammatory and autoimmune disease drug discovery and development (Masters with 8+ years of experience, Bachelors with 10+ years of experience)
* Strong expertise in immune cell biology (innate and adaptive immunity), cell signaling, and immunological assay development
* Hands-on experience with relevant techniques, including, biochemical and cellular assay development, tissue culture, flow cytometry, and functional genomics techniques
* Experience with disease models of inflammation and/or autoimmunity
* Ability to manage multiple priorities in a fast-paced environment
* Strong problem-solving skills and ability to work independently and in team settings
* Collaborative mindset with strong interpersonal skills
* Strong analytical skills for evaluating scientific data and external opportunities
* Excellent communication skills for translating complex science into business-relevant insights
*
* Preferred Qualifications:

*** Prior experience in biotech/pharma drug discovery or translational research (5+ years)
* Experience working with small molecule, biologics, and/or cell based therapeutic drug discovery and development
* Strong technical expertise in multiparametric flow cytometry (e.g. 15+ colors)
* Experience with multiomics analyses (e.g. genomic, transcriptomic, proteomics, etc.)
* Experience in due diligence and business development support is highly desirable

Job Level: Management
** Additional Information
** The base compensation range for this role is: $-$Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance. In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families
* physical, financial, emotional,
* and
* social well-being*; including, but not limited to:
* Medical, Dental, Vision, & Life insurances
* Fitness & Wellness programs including a fitness reimbursement
* Short- and Long-Term Disability insurance
* A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
* Up to 12 company paid holidays + 3 paid days off for Personal Significance
* 80 hours of sick time per calendar year
* Paid Maternity and Parental Leave…
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