Scientist​/Sr. Scientist, Chemical Biology

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

We are seeking first-rate chemical biologists to help us pioneer this uncharted frontier of drug discovery.

A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1] , but there are many other possible perturbation types whose potential remains unrealized.

General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).

Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2 , 3 , 4 ], and our technology holds the same promise.

We are seeking an experienced chemical biologist to be a founding member of our Platform/Drug Discovery Team. In this position, you will work closely with our Biology Team in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.

Your responsibilities will include: supervising synthetic efforts with our CROs, designing and performing both low and high-throughput screening assays, managing compound libraries, performing mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

• PhD in Chemical Biology, Medicinal Chemistry, Pharmacology, or related field.
• Industry experience is desirable, but the ability to work hard and learn fast is more important to us.
• Deep understanding of small-molecule drug discovery and its relationship to human disease.
• Strong experience with:
  • Hit finding and hit-to-lead studies
  • HTS and phenotypic assay development and screening
  • Small molecule binding affinity assays
  • PPI techniques (e.g. BRET, APEX/BioID, Alpha Screen)
• Proficiency in:
  • Platform development
  • Compound management
  • Disease model development
  • Biochemical assay development
• Nice to have:
  • Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc
  • Familiarity or experience with PROTAC/next-gen IPM technologies
  • Biophysical screening techniques such as SPR or fluorescence anisotropy
  • DEL experience
  • Experience with med-chem optimizations: SAR, PK/PD, etc
  • Computational drug discovery experience
  • Prior experience on teams that have successfully advanced research to the clinic
  • Experience managing others
• Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
• Top tier medical, dental, and vision coverage + One Medical membership.
• Education and health/fitness incentive programs.
• Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.
• Reading budget! We will buy you books.
• Located in the MBC Bio Labs at 135 Mississippi Street, an entrepreneurial hub full of the…