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Scientist – Peptide & Oligonucleotide Chemist

Job in San Francisco, San Francisco County, California, 94199, USA
Listing for: Undisclosed Biotech Startup
Full Time position
Listed on 2025-12-26
Job specializations:
  • Research/Development
    Research Scientist
  • Healthcare
Salary/Wage Range or Industry Benchmark: 100000 - 140000 USD Yearly USD 100000.00 140000.00 YEAR
Job Description & How to Apply Below

Base Pay Range

$/yr - $/yr

About Us

We’re a stealth-mode, venture-backed biotech startup based in the Bay Area, developing breakthrough technology at the intersection of genetics and reproductive health. We’re backed by world‑class investors, have raised our first institutional round, and are now expanding our team. We operate our primary lab in the Peninsula and we’re in the process of getting access to additional access to world‑class chemistry facilities in the East Bay.

Applicants must be willing to commute between campuses.

About the Role

We’re seeking a scientist with deep expertise in nucleic acid analog synthesis and assay development to join our R&D team. In this role, you’ll collaborate closely with our founding team to develop and optimize our cellular assays. You will design and optimize the synthesis of nucleic acid analogs, characterize the synthetic output, and assist in the evaluation of reagent efficacy. This is a hands‑on, high‑impact role at the earliest stage of the company;

perfect for someone excited to shape the future of fertility and reproductive health. PhD (or equivalent experience) in organic chemistry, biomolecular chemistry, chemical biology, nucleic acid chemistry, or closely related field required.

Required Skills
  • Extensive, hands‑on experience with synthetic nucleic acid or peptide chemistry
  • Experience with PNA OR a closely related polymer synthesis workflows and troubleshooting
  • Knowledge of nucleotide or nucleic acid binding principles: hybridization thermodynamics, mismatch discrimination, duplex stability, etc.
  • Proficiency in peptide and nucleic acid purification and characterization via HPLC, LC‑MS, etc
  • Ability to design and interpret in‑vitro / in‑silico binding or stability assays
  • Excellent communication and organizational skills
  • Excited to work in a dynamic, early‑stage startup atmosphere
  • Motivated, independent, and excited to help build new technology
  • Comfort working across multiple lab sites/campuses
Preferred Skills
  • Experience with in vivo or cellular assays involving nucleic acid probes
  • Knowledge of alternative nucleic acid backbone chemistries (e.g., morpholino, modified RNAs)
  • Prior startup or technology development experience
Pay Range and Compensation Package

This is a full‑time, on‑site role based in the San Francisco Bay Area, CA. Relocation stipend available.

  • Salary Range: $100,000–$140,000, depending on experience
  • Equity:
    Meaningful early‑stage equity as part of the founding team
  • Benefits: 401(k) with company matching, healthcare, vision and dental coverage
Equal Opportunity Statement

We’re committed to building a diverse and inclusive team. We welcome applicants of all backgrounds, experiences, and identities. We do not discriminate on the basis of race, color, religion, sex (including pregnancy, sexual orientation, and gender identity), ancestry, marital status, national origin, religion, age, disability, genetic information, veteran status, or any other protected status under applicable laws.

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