Scientist, Antibody Discovery and Engineering

Scientist, Antibody Discovery and Engineering

Scientist – Antibody Discovery and Engineering

Company: Stealth-mode biotechnology venture

A stealth-mode biotechnology company in San Francisco is seeking a highly motivated Scientist to join their Antibody Discovery and Engineering team. The successful candidate will contribute to the discovery and optimization of therapeutic antibodies using advanced technologies such as phage/yeast display, mutagenesis, and integrated leads screening. This role offers an exciting opportunity to work in a fast-paced environment focused on developing next-generation biologics.

This is an on-site position.

• Lead VHH and related discovery campaigns using yeast and phage display technologies, including experimental design, execution, and troubleshooting.
• Perform hands‑on antibody discovery workflows, including library construction, panning, output screening, single‑clone characterization, and data summarization.
• Analyze binding kinetics, specificity, and stability of antibody leads using biochemical and biophysical assays such as SPR, BLI, ELISA, and cell‑binding studies.
• Accurately document experiments and maintain electronic lab notebooks (Benchling) in a timely manner.
• Conduct in‑depth data analysis and effectively communicate results in project meetings, ensuring alignment with timelines and goals.
• Collaborate with cross‑functional teams (protein science, biology, and in vivo pharmacology) to optimize antibody properties.
• Coordinate with CROs on activities related to animal immunization, protein production, and characterization.
• Perform additional duties as assigned.

• Education:
  
  Master’s degree in Biology or a related field with 5+ years of experience in antibody discovery, or a Ph.D. with 2+ years of relevant experience.
• Proven ability to design and apply in vitro antibody discovery display technologies (e.g., phage display, yeast display) for antibody discovery and/or engineering.
• Strong molecular biology skills, including PCR, DNA/RNA isolation, plasmid preparation, gel extraction, cloning, and Sanger sequencing analysis.
• Hands‑on experience with SPR (Carterra LSA, Biacore) or BLI (Octet, Gator), ELISA and flow cytometry.
• Demonstrated scientific productivity and independence, with strong problem‑solving skills.
• A strong desire to work in a dynamic startup environment is essential.
• Comfortable working in an environment involving radio labeled therapeutics.

• Strong communication skills to work within a multidisciplinary team environment.
• Experiences leading project from antibody discovery to drug candidate selection.
• Knowledgeable in recombinant protein production and characterization.
• Proficiency with bio‑tools such as Graph Pad Prism, Geneious, Flow Jo and Benchling.
• Demonstrated track record in managing multiple projects and prioritizing tasks to meet schedules and timelines.
• Excellent written and oral communication skills and the ability to present effectively to teams.

• Title and scope commensurate with experience.
• Competitive compensation package including equity participation.

• Opportunity to shape the antibody discovery engine of a cutting‑edge radioligand therapy company.

• Mid‑Senior level

• Full‑time

• Research, Analyst, and Information Technology