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Principal Scientist LC-MS

Job in San Francisco, San Francisco County, California, 94102, USA
Listing for: VRS Recruitment
Full Time position
Listed on 2026-10-31
Job specializations:
  • Science
    Research Scientist, Pharmaceutical Science/ Research
Salary/Wage Range or Industry Benchmark: 140000 - 165000 USD Yearly USD 140000.00 165000.00 YEAR
Job Description & How to Apply Below

Principal Scientist – LC-MS
Carlsbad, CA

An exciting opportunity for an experienced Analytical Chemist to join an innovative biopharmaceutical organization developing novel therapeutics.

This position offers an excellent blend of hands-on analytical science, project leadership, and regulatory involvement, with the opportunity to take ownership of projects and potentially build a team.

Primary Responsibilities
  • Lead analytical development and QC activities supporting drug substance and finished drug products.
  • Develop, optimize, and validate LC-MS and other analytical methods.
  • Manage internal projects and external analytical partnerships.
  • Oversee release testing, stability studies, and analytical investigations.
  • Contribute to regulatory submissions, including INDs, IMPDs, and CMC documentation.
  • Work across both R&D and routine QC activities, retaining significant hands-on laboratory involvement.
Candidate Qualifications
  • PhD with 3+ years or BS/MS with 5+ years of relevant industry experience.
  • Strong hands-on LC-MS experience, including method development and validation.
  • Experience working in a GMP-regulated pharmaceutical or biotechnology environment.
  • Understanding of ICH/FDA guidelines and phase-appropriate analytical methods.
  • Experience with oligonucleotides highly desirable; proteins and peptides also of interest.
  • Strong project management, communication, and problem‑solving skills.
Salary:
  • $140-165K annual base salary (or MORE!) for qualified candidates
  • Help with relocation
  • Excellent benefits inc. Health/Dental/Vision, 401k with march, etc.

Reference#: VRS
2435

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