Antibody Engineering Scientist/Senior Scientist
Listed on 2026-01-02
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Engineering
Research Scientist, Biotechnology -
Research/Development
Research Scientist, Biotechnology
Antibody Engineering Scientist/ Senior Scientist
Join to apply for the Antibody Engineering Scientist/ Senior Scientist role at Oxford Bio Therapeutics.
Oxford Bio Therapeutics (OBT) is a clinical-stage biotechnology company developing antibody therapeutics for the treatment of cancer. You will play an integral role in the pre‑clinical development of novel immuno‑oncology therapeutics. OBT’s OGAP® platform is the world's largest cancer‑specific membrane protein library, directly measuring plasma membrane protein expression in patient tumors. OGAP is used to identify novel, highly tumor‑specific antigens for first‑in‑class antibody drug conjugates (ADC), bispecific T‑cell engagers (BITE®), and chimeric antigen receptor (CAR) targets.
Our lead asset, OBT
076, is an ADC in Phase 1b clinical development. The pipeline balances internal programs focused on ADCs and checkpoint regulators with external partnerships with Roche, Boehringer Ingelheim and Zymeworks.
We are seeking a highly motivated and innovative Scientist to drive the discovery and optimization of mAbs and multi‑specific antibody formats. This lab‑based role will spearhead sequence and structure‑guided protein engineering initiatives, leveraging AI/ML tools and display technologies to enhance antibody affinity, specificity, stability, and develop ability. Candidates must be willing to work onsite 5 days a week.
Key Responsibilities Antibody Engineering- Design, engineer, and optimize antibodies to improve binding affinity, specificity, stability, and develop ability.
- Lead affinity maturation and develop ability campaigns using directed‑evolution and sequence & structure‑based design.
- Develop, screen and validate display library‑based workflows.
- Develop and validate affinity binding assays (SPR), interpret complex kinetic and affinity datasets, and integrate findings into project decisions.
- Engineer conditionally active antibody variants (e.g., enhanced binding at low pH, cleavable peptide masks).
- Humanize mouse antibodies.
- Use protein structure modeling tools such as PyMol.
- Affinity‑tune monoclonal antibodies to achieve high, medium, or low binding affinities.
- Define and oversee end‑to‑end protein engineering workflows, ensuring resource efficiency, timeline adherence, and risk management.
- Mentor and guide scientists, setting high standards for data quality and fostering career development.
- Collaborate cross‑functionally with Antibody Discovery, Protein Sciences, Bioinformatics, AI, and Project Management teams.
- Cultivate a collaborative, data‑driven, and innovative research culture aligned with company goals.
- Work with AI scientists to optimize antibody properties (affinity, specificity, develop ability) and use display technologies to test, optimize, and select final leads.
- Leverage AI/ML‑enabled structural tools for modeling and hypothesis generation.
- Drive continuous improvement of workflows and methodologies.
- PhD. in Molecular Biology, Biochemistry, or related discipline.
- 7+ years of relevant industry experience in therapeutic antibody engineering OR exceptional postdoctoral training.
- Must have experience with display technologies (phage, yeast, or mammalian display).
- Expert in library creation, selection, and enrichment analysis.
- Proven track record in affinity maturation, antibody develop ability, multi‑specific optimization and library‑based engineering.
- Expertise in structure‑guided protein engineering.
- Deep knowledge of antibody structure‑function relationships and protein engineering strategies.
- Hands‑on experience with display technologies (phage, yeast, mammalian) and develop ability characterization (DSF/DSC‑light, DLS, SEC).
- Working knowledge of AI/ML tools for protein structure prediction and optimization.
- Engineering and optimizing bi‑or multi‑specific antibody formats, T‑cell engagers, ADCs, and other complex biologics is highly desirable.
- Experience with antibody humanization, affinity maturation, and optimization of antibody develop ability for therapeutic applications is preferred.
- Experience in engineering…
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