Scientist, IHC

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Oxford Bio Therapeutics (OBT) is a dynamic, growing, international biotechnology company based in Oxford, UK, and San Jose, CA. We are a clinical stage oncology company with a pipeline of immuno-oncology and antibody-drug conjugate-based therapies. OBT’s IO discovery process provides unique insight into the cancer‑immune cell synapse and has identified several novel IO candidates for cancer therapy. Discovery of novel tumor antigens and immune cell surface proteins at OBT is performed using the proprietary Oxford Genome Anatomy Project (OGAP®) database.

OBT currently has one ADC in Phase 1b clinical trials in collaboration with Menarini.

We are seeking a motivated and detail‑oriented Scientist to join our histopathology lab within the Target Validation Team at our San Jose, CA site. The candidate will independently execute the necessary histopathology techniques for evaluating oncology therapeutic targets, supporting our target validation efforts through IHC, IF, ISH, slide scanning, whole‑slide image analysis, and troubleshooting.

• Independently design and execute the selection of in‑house antibody clones to develop, validate and utilize chromogenic IHC assays against novel cancer drug targets.
• Design and perform single and multiplexed IHC, ISH, IF and similar assay experiments to support therapeutic drug development decision making.
• Process tissues and cell pellets into FFPE and frozen sample blocks; section FFPE and frozen samples, and perform staining primarily using Leica Bond autostainers.
• Digitize microscope slides using slide scanners and independently summarize results of lab experiments in ELN and PowerPoint presentation formats in a timely manner.
• Collaborate effectively in a matrix‑managed organization to drive advancement of early‑stage projects into translational and clinical development.
• Be relied upon as a technical expert in the IHC field; provide guidance to colleagues and collaborators, and mentorship to more junior lab colleagues.
• Perform general day‑to‑day lab tasks including timely archiving of new slides and samples, equipment maintenance, consumables ordering, shipping/receiving, etc.

• PhD +4 years, or Master’s +6 years, or Bachelor’s +8 years or more of hands‑on experience working in histology and IHC related labs, preferably supporting cancer research in an industry setting.
• Extensive hands‑on experience developing, utilizing, and interpreting immunohistochemistry (IHC) assays against novel protein targets, using both single and multiplex IHC techniques primarily on FFPE sample slides.
• Extensive hands‑on experience in laboratory histology, including preparation of tissue samples into FFPE and FF blocks, preparation of cell pellet control blocks, cryostat and microtome sectioning, troubleshooting chromogenic IHC and ISH experiments, and independently identifying appropriate next steps in the development of robust, sensitive and specific tissue biomarker assays.
• Experience with Leica Bond autostainers and reagents relevant to optimizing new IHC assays, typically chromogenic assays.
• Experience with microscope slide scanners for brightfield and fluorescent imaging, and general experience utilizing whole‑slide image analysis software such as HALO.

• Knowledge in cancer biology, immuno‑oncology, and tumor histopathology are each a plus.
• Strong track record of developing and implementing strategic initiatives to improve scientific and/or operational activities.
• Relevant experience working with service providers and CROs in the histology space.
• Excellent organization skills, and previous successes working a growing and fast‑paced work environment.
• Experience regularly presenting IHC assay results in group settings.
• Top candidates will be collaborative and team oriented, creative problem solvers, resilient to change, and interested in learning opportunities.
• Experience with cell culture and related molecular biology assays (WB/ELISA/etc.) are additionally a plus.

• Medical, dental and…