Associate​/Scientist, Protein-Biologic Discovery

About Oxford Bio Therapeutics:

Oxford Bio Therapeutics (OBT) is a dynamic, rapidly‑growing, international biotechnology company based in Oxford, UK, and San Jose, CA. We are a clinical‑stage oncology company with a pipeline of immunooncology and antibody‑drug conjugate‑based therapies. OBT's IO (Immuno‑Oncology) discovery process provides unique insight into the cancer‑immune cell synapse and has identified several novel IO candidates for cancer therapy. Discovery of novel tumor antigens and immune cell surface proteins at OBT is performed using the proprietary Oxford Genome Anatomy Project (OGAP®) database.

OBT currently has one ADC in phase 1b clinical trials in collaboration with Menarini, and target discovery collaborations with Boehringer Ingelheim, Zymeworks and Roche.

OBT is seeking an experienced, creative and motivated scientist to contribute to our company's Discovery Biologics Protein Science group. Work independently, and in a matrix, to lead the development of antigen antibodies against novel targets discovered by Oxford Biotherapeutics, headquartered in the UK. The successful candidate will be involved in multiple aspects of the production of recombinant proteins, monoclonal antibodies, multi‑specific scaffolds, and novel protein modalities to enable all aspects of Early Discovery and Validation Research.

• Be a contributor to the discovery and development of antibody therapeutics for oncology and immune oncology for novel targets.
• Support recombinant protein and bi‑ and multi‑specific antibody discovery plans (immunogen design, assay development, screening, and functional characterization methods)
• Support biological discovery through different platforms of protein and antibody discoveries.
• Responsible various target projects to execute protein production and antibody discovery/optimization in various platforms
• Generate target over‑expressing cell lines for antibody discovery work
• Develop strategies to express, purify, and analyze proteins for novel tumor targets expressed in mammalian cells.
• Perform purification using AKTA/HPLC systems and maintain equipment.
• Conduct antibody characterization of antibodies including binding affinity and binding kinetics through Octet/Biacore, epitope binning/mapping, and functional assays.
• Troubleshoot experimental issues with guidance; contribute to process and assay transfers.
• Mentor lower‑level colleagues and assist in scientific optimization & development.
• Analyze data, interpret results, identify problems, and develop trouble‑shhooting plans
• Maintain accurate documentation and follow laboratory safety procedures.
• Knowledge of the biologics drug discovery process and representation of the protein science function at project team meetings.
• Compliances with data management, laboratory notebook policy, and laboratory safety.

Requirements:

• Ph.D. in biological sciences or related fields with 4+ years of post‑Ph.D., or MS with 6+ or BS with 8+years of experience in biopharma industry or closely related scientific discipline, preferably in a fast‑paced startup environment.
• Experience in molecular biology or/and biochemistry, including gene manipulation, subcloning, expression vector modifications, and protein expressions in HEK & CHO cell systems
• Experience in developing and optimizing recombinant proteins and bi‑ and multi‑specific antibody formats across multiple parameters is preferred.
• Extensive experience in human protein and antibody purification techniques, including affinity chromatography, ion exchange chromatography (HIC), ion exchange chromatography (IEX), and size exclusion chromatography (SEC). Proficiency in operating and troubleshooting modern chromatography hardware and software, such as Cytiva AKTA systems and Agilent HPLC and UPLC.

• Antibody drug discovery experience for immune oncology in biopharmaceutical industry is a plus.
• Ability to independently manage projects and deliver results on stringent timelines with high quality is plus

One of our top priorities is to maintain the health and wellbeing of our employees and their families. To achieve this goal, we…