Senior Manager - Bioinformatics Operations

Senior Manager - Bioinformatics Operations

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Kforce is working with a client located in San Juan Capistrano, CA that is seeking a highly skilled and motivated Senior Manager of Bioinformatics Operations to lead a regional team focused on delivering clinical-grade bioinformatics applications that drive precision diagnostics. This is a hands‑on leadership role for someone who thrives in a fast‑paced, regulated environment and is passionate about operational excellence in genomics.

As the regional lead, you'll oversee the development, validation, and support of automated bioinformatics pipelines used in genetic laboratories. You'll work closely with cross‑functional teams— including lab scientists, product owners, IT, and bioinformatics engineers—to ensure high‑quality, stable, and efficient applications that meet clinical turnaround times and compliance standards.

• Lead and mentor a team of 5‑7 bioinformaticians and contractors, fostering accountability and growth
• Manage daily operations of bioinformatics pipelines, ensuring service levels and turnaround targets are met
• Collaborate with lab operations to support sample processing and troubleshoot production issues
• Oversee incident response, system health monitoring, and performance metrics
• Drive CI/CD practices and workflow orchestration using tools like Nextflow, Snakemake, and Service Now
• Maintain data integrity, compliance documentation, and secure archival of clinical data
• Partner with engineering teams to enhance automation and implement data‑driven process controls
• Support software version upgrades, tech transfers, and product launches in collaboration with R&D
• Align with other regional managers to standardize practices and share operational insights
• Implement training frameworks and competency assessments to upskill team members

• 7+ years of experience in bioinformatics, software engineering, or related fields
• Strong technical background in Python, R, shell scripting, SQL, and AWS
• Experience with sequence aligners, variant callers, and interpretation tools
• Proven leadership in managing technical teams and delivering production‑grade solutions
• Familiarity with regulated environments (CAP, CLIA, FDA) and handling sensitive patient data
• Excellent communication, project management, and problem‑solving skills
• Comfortable working across abstraction levels—from strategy to technical execution

• MSc or PhD in Bioinformatics, Computer Science, or related discipline
• Agile certification and experience with international teams
• Experience with LIMS, variant interpretation platforms, and cloud migration

This is a strategic and impactful role for a bioinformatics leader who is ready to shape the future of clinical genomics operations. You'll be part of a mission‑driven organization that values innovation, collaboration, and continuous improvement.

Benefits include comprehensive health coverage, paid time off, retirement plans with company match, education assistance, and career development programs.

The pay range is the lowest to highest compensation we reasonably in good faith believe we would pay at posting for this role. We may ultimately pay more or less than this range. Employee pay is based on factors like relevant education, qualifications, certifications, experience, skills, seniority, location, performance, union contract and business needs. This range may be modified in the future.

We offer comprehensive benefits including medical/dental/vision insurance, HSA, FSA, 401(k), and life, disability & ADD insurance to eligible employees. Salaried personnel receive paid time off. Hourly employees are not eligible for paid time off unless required by law. Hourly employees on a Service Contract Act project are eligible for paid sick leave.

Note:

Pay is not considered compensation until it is earned, vested and determinable. The amount and availability of any compensation remains in Kforce's sole discretion unless and until paid and may be modified in its discretion consistent with the law.

This job is not eligible for bonuses, incentives or commissions.

Kforce is an Equal Opportunity /Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, pregnancy, sexual orientation, gender identity, national origin, age, protected veteran status, or disability status.