Sr Principal Eng - Process Engineering

Job Function:

Supply Chain Engineering

Job Sub Function:

Process Engineering

Job Category:

Scientific/Technology

All Job Posting Locations:

Schaffhausen, Switzerland

Senior Principal Engineer – Process Engineering (GET PE – Synthetics Drug Product Manufacturing)

This is an onsite/hybrid role.

• Belgium & Italy – Requisition Number: R-071736
• Puerto Rico – Requisition Number: R-076777
• Switzerland – Requisition Number: R-076783

Applications will be considered as a single submission.

As the GET PE – Synthetics Drug Product Manufacturing Senior Principal Engineer, you will lead early design inputs and technical strategy for synthetic drug product manufacturing processes within strategic capital projects, network studies, and technology platforms across IMSC. You will provide deep technical expertise in the synthetic controlled bioburden drug product manufacturing (OSD and innovative forms such as semi-solid) and drug product intermediate through bioavailability enhanced technologies, while supporting solving and optimization activities at internal and external manufacturing sites.

Joining our global engineering group, you will collaborate with high‑performing, multi‑functional teams across multiple sites and functions. This role offers a dynamic and inspiring work environment with significant opportunities to influence technology direction, standardization, and capability building across the network.

• Lead the intake, scoping, prioritization, and resolution of synthetics controlled bioburden–drug product manufacturing related technical requests across global sites
• Lead and influence early‑phase process design and domain expertise for oral solid dose (OSD) products, covering both batch and continuous manufacturing platforms and new innovative drug product forms
• Lead and influence early‑phase process design and domain expertise for bioavailability enhanced technologies, including amorphous solid dispersions (ASD) with a strong emphasis on spray drying, as well as other technologies such as Self‑Emulsifying Drug Delivery Systems (SEDDS) and other innovative drug product intermediate formulation approaches
• Ensure robust, fit‑for‑purpose process design while promoting standardization and platform approaches where they make valuable contributions
• Provide expert input and alignment on key process, equipment, and technology selection decisions for drug product manufacturing
• Actively collaborate with other functions such as R&D, MSAT, Quality, EHS and Operations leads across synthetic drug product sites
• Find opportunities for harmonization, shared solutions, and best‑practice exchange across the network
• Foster a culture of collaboration to reduce duplication, accelerate implementation, and improve speed‑to‑market
• Maintain strong connections with industry experts and external networks (e.g., ISPE) to bring innovative drug product manufacturing solutions into the organization
• Ensure alignment with enterprise strategies, GMP requirements, and technology roadmaps
• Collaborate with External Manufacturing teams to prioritize support and resolve issues for high‑impact programs and partners

Education:

• Minimum of a Master’s degree or equivalent experience in Engineering, Pharmaceutical Sciences, or a related technical field is required

Experience and Skills:

• Minimum 10 years of relevant experience in synthetics controlled bioburden drug product manufacturing, with a strong focus on oral solid dose (OSD) processes and innovative technologies (e.g., semi-solid) in drug product pharmaceutical manufacturing environments
• Demonstrated expertise in bioavailability enhanced technologies, including ASD (amorphous solid dispersions) with deep knowledge of spray drying, and SEDDS or similar innovative enabling formulation approaches
• Proven experience with OSD controlled bioburden manufacturing, including batch and continuous manufacturing processes and associated equipment
• Strong understanding of cGMP environments and regulatory expectations for controlled bioburden-drug product manufacturing. Aseptic capability is a plus
• Proven track record of leading…