Principal Technical Program Manager

The Role Moderna is seeking an experienced and visionary Principal Technical Program Manager (TPM) to join Digital Commercial Engineering (DCE) team based in Seattle, WA. This role will be pivotal in supporting Moderna’s Commercial endeavor across multiple geographies, helping to drive digital innovation and execution that enables Moderna to deliver on its mission of creating transformative medicines for patients around the world.

As a senior member of the DCE organization, you will partner with business stakeholders across Moderna’s Commercial team to deeply understand their digital and operational needs, translate business requirements into actionable technical roadmaps, and work closely with multiple engineering, data and product teams to deliver scalable, compliant, and high-impact digital solutions.

You will operate at the intersection of business and technology—aligning commercial strategy with digital delivery—while influencing strategic prioritization, operational planning, and stakeholder engagement across geographies.

Here’s What You’ll DoPartner with Business Stakeholders across Moderna’s Commercial Country teams to deeply understand digital, customer, and business needs. Define and document clear business and technical requirements, translating them into actionable deliverables that shape product and data direction, resourcing, and execution plans in collaboration with Digital Product, Data, and Engineering teams.

Lead end-to-end program planning and execution, developing integrated delivery roadmaps, managing scope, schedules, dependencies, and budgets, while proactively identifying and mitigating risks and challenges to ensure alignment, momentum, and on-time delivery of commercial initiatives.

Facilitate cross-functional collaboration among Product, Data, Engineering, and Business teams to drive consensus on technical and data solutions, manage upstream and downstream data dependencies, and ensure timely, high-quality delivery.

Partner closely with Engineering teams to ensure commercial initiatives effectively leverage enterprise data capabilities, dependencies, quality, governance, and delivery across markets.

Drive data-informed prioritization and transparent reporting to provide visibility into program progress, key decisions, risks, and outcomes, while representing the Digital portfolio in leadership forums to influence strategic direction, communicate business impact, and ensure alignment across commercial functions.

Champion operational excellence in digital delivery, promoting modern program management practices, process optimization, and continuous improvement across teams.

Mentor and coach TPMs and project managers, strengthening delivery capabilities and contributing to the maturity of the TPM discipline within Moderna Digital.

Here’s

What You’ll Bring to the Table (Basic Qualifications)
Bachelor’s degree in Computer Science, Engineering, or a related technical field (or equivalent professional experience).10+ years of overall professional experience, with at least 6+ years in technical program management for complex, cross-functional software or digital initiatives.

Proven ability to manage large-scale technical programs with multiple stakeholders, spanning business and technology functions. Experience managing programs with multi-market scope.

Strong analytical and communication skills, with the ability to influence at multiple organizational levels. Demonstrated success in partnering with business leaders to translate strategy into executable roadmaps.

Degree in advanced technology, or 5+ years of technical specialist, design and architecture experience. Proven skills in technical design and architecture.

Experience in commercial digital systems, customer platforms,…