Scientist - Alzheimer's Disease

Scientist I – Human Cell Types – Alzheimer’s Disease

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The mission of the Allen Institute is to understand the principles that govern life, and to advance health. Our creative and multi‑dimensional teams focus on answering some of the biggest questions in bioscience. We accelerate foundational research, catalyze bold ideas, develop tools and models, and openly share our science to make a broad, transformational impact on the world. The mission of the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease.

Using a big science approach, we generate useful public resources, drive technological and analytical advances, and discover fundamental brain properties through the integration of experiments, modeling, and theory.

The Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) consortium strives to achieve a deep molecular and cellular understanding of the early pathogenesis of Alzheimer’s disease (AD). Leveraging advances in quantitative neuropathology and next‑generation single‑cell molecular profiling technologies we are generating large‑scale data sets from well‑characterized donors that span the spectrum of AD pathology to comprehensively map human brain cell types across aging and disease.

These data along with tools for their use are made freely and publicly available.

We are seeking a highly motivated Scientist to contribute to this effort by designing and executing experiments at the interface of neuroanatomy, single‑cell genomics, and histology. The Scientist will generate precisely dissected, high‑quality human brain tissue samples, optimize and validate molecular and single‑cell assays, and execute experiments (e.g., in situ hybridization, immunostaining) to validate computational findings. Working closely with experts in neuropathology, spatial transcriptomics, and computational analysis, the Scientist will help advance high‑resolution molecular atlases of the human brain in health and disease.

The ideal candidate will have a strong foundation in molecular neuroscience, experience with single‑cell transcriptomic and/or epigenomic assays, and a working knowledge of Alzheimer’s disease biology. Familiarity with human neuroanatomy and enthusiasm to deepen anatomical expertise are also essential.

We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment.

We are an equal‑opportunity employer and strongly encourage people from all backgrounds to apply for our open positions.

• Contribute to the design and execution of large‑scale single‑cell genomics experiments
• Participate in the development and testing of new single‑cell methods and protocols
• Optimize protocols for challenging samples , troubleshoot workflows for variable tissue quality, and evaluate tissue and sequencing library quality using standard metrics
• Conduct basic analysis of single‑cell genomics data, including benchmarking of new methods
• Design and execute experiments to validate and extend computational results and generate novel biological insights
• Present progress in group meetings and at scientific conferences, and contribute to peer‑reviewed publications
• Assist in management of tissue acquisition and sample tracking
• Maintain meticulous experimental records to ensure reproducibility across tissue donors and adherence to best practices for tissue handling, biosafety, and data integrity
• Actively contribute to a collaborative environment focused on scientific rigor and methodological innovation

Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects management’s assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

• PhD degree in Neuroscience, Molecular Biology, Genomics, or related field, or equivalent combination of degree and…