Sr. Associate Scientist or Scientist, RNA Process Development
Job in
Seattle, King County, Washington, 98127, USA
Listing for:
TechDigital Group
Full Time
position
Listed on 2025-12-02
Job specializations:
-
Research/Development
Research Scientist, Biotechnology, Biomedical Science
Job Description & How to Apply Below
Sr. Associate Scientist or Scientist, RNA Process Development
Job Title– Sr. Associate Scientist or Scientist, RNA Process Development
Location:
Seattle, WA
* 100% Onsite
Top
Skills:
Proficiency with biochemical techniques to analyze oligonucleotides (PAGE and CE)Proficiency with analytical IP-RP chromatography for RNA (including mRNA) purityExperience working with, storing, and analyzing purified nucleic acids and proteinsExperience with optimizing molecular cloning reactionsExperience with gene editing primary human cells or immortalized cell-linesSeeking a highly motivated Sr. Associate Scientist, or Scientist, to work in a fast-paced PD environment applying rigorous biochemical principles towards developing and characterizing ligated oligonucleotides for gene editing applications. As a part of the Gene Delivery and Editing Process Development (GDEPD) organization, the ideal candidate will possess sufficient experience with handling, manipulating, and characterizing in vitro produced RNA oligomers (50 – 200 nt).
A successful scientist will directly employ molecular cloning, biophysical and analytical tools to develop our next-generation gene edited therapies through the development of RNA oligomers. An outstanding candidate will be driven by a desire to create, optimize, and define processes with speed in a collaborative environment.
Key Responsibilities:
Design and execute nucleic acid ligation reactions using "splint ligation" methodologyDesign and execute ion-pairing (IP) reversed-phase (RP) chromatography methodsPerform purification of oligonucleotides using chromatography and/or preparative PAGEDesign and evaluate the performance of new biophysical assays to identify and assess CQA'sManage samples and data related to gene editing platform process developmentProvide experimental design and executional support to team members in adjacent and related functions (e.g. clinical development programs, high throughput process development, etc.)Actively participate and support lab maintenance and continuous improvement initiativesMaintain accurate and detailed laboratory notebook and documentationSummarize and present data in group meetings and contribute to group discussionsAuthor technical reports, study memos, and protocolsBasic Qualifications:
STEM degree with 2+ years of relevant industry experience; title/compensation will be commensurate with education, experience, and skillsetProficiency with biochemical techniques to analyze oligonucleotides (PAGE and CE)Proficiency with analytical IP-RP chromatography for RNA (including mRNA) purityExperience working with, storing, and analyzing purified nucleic acids and proteinsIndependently motivated with the ability to work in teamsAbility to communicate clearly and concisely through oral presentation and technical writingAbility to leverage literature, internal and external resources to solve problems and develop new technologiesPossess a growth mindset and the ability to thrive in a fast-paced, highly collaborative environmentPreferred Qualifications:
Degree in biological or chemical engineering, biochemistry, or bio-related fieldExperience with optimizing molecular cloning reactionsExperience with gene editing primary human cells or immortalized cell-linesExperience with solid-phase oligonucleotide synthesisExperience with bioinformatic tools used to predict RNA secondary structureExperience with JMP for DoE design and analysis#J-18808-Ljbffr
Position Requirements
10+ Years
work experience
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