Research Scientist IV - Coler Lab

A fully supported Scientist IV position is available in the cross-disciplinary Coler Lab (Coler Lab - Center for Global Infectious Disease Research) to characterize immune response of novel vaccines and immune pathology associated with tuberculosis and co‑morbidities, as well as how the microbiome and associated ecological and evolutionary factors affect our immune response. Previous experience in cellular immunology is required. Additionally, we seek candidates with experience in bioinformatics and/or computational approaches to analyzing vaccine‑induced immune responses and the microbiome.

Plan, design, and execute research development activities in support of funded research projects. Design approaches or hypotheses to be tested and methodology to be used; design specific phases of research projects. Perform experimental procedures and make detailed observations; analyze and interpret data. Apply computational methods to complex biological systems. Develop computational infrastructure for processing and analysis of next‑generation sequencing datasets, including isolate and metagenomic studies.

Extract nucleic acid from various biological sources and prepare next‑generation sequencing libraries. Normalize, integrate, and analyze datasets of multiple modalities. Work closely with the principal investigator on the development of technical proposals, presentations, manuscripts, and grants. Plan and conduct work requiring independent judgment in the evaluation, selection, and substantial adaptation/modification of standard techniques, procedures, and criteria. Maintain accurate documentation; ensure protocols are available to research team members.

Use a wide application of complex principles, theories, and concepts in your specific scientific discipline. Guide technical staff and provide training in protocols and laboratory techniques in BSL2 and BSL3 settings. Write original reports incorporating data analysis and meet specifically agreed upon deadlines. Contribute proportional intellectual content to team efforts.

PhD or M.D. in Molecular or Cellular Biology, Biochemistry, or another closely related field.

Minimum of four (4) years experience in the required field of specialization.

Prior experience with laboratory management or other relevant research field.

• Experience and technical skills in next‑generation sequencing, multi‑omics approaches, deep understanding of immunology and/or human biomarker research.
• Demonstrated coding skills in one or more programming languages (Python, R, shell scripting, or similar).
• Proficiency in MS Office, scientific data/graphics programs, bioinformatics, and biostatistics.
• A strong track record of publication.
• Experience working under Biosafety Level 2 or 3 (BL2/BL3) conditions.
• Willingness and ability to work under BL3 conditions with appropriate training.
• Experience working with small animal models of infectious diseases.
• Excellent oral and written communication skills in English.
• Self‑motivated, highly organized, and able to work on teams.

$ - $ per year

This compensation range was calculated based on full‑time employment (2080 hours worked per calendar year). Offers are determined by multiple factors including equity, skills, experience, and expertise, and may vary within the range provided.

This compensation range is specific to Seattle; positions located outside of Seattle may be compensated differently depending on various factors.

Seattle Children’s offers a generous benefit package, including medical, dental, and vision plans, 403(b), life insurance, paid time off, tuition reimbursement, and more. Additional details on our benefits can be found on our website (Use the "Apply for this Job" box below)..

Hope. Care. Cure. These three simple words capture what we do at Seattle Children’s – to help every child live the healthiest and most fulfilling life possible. As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures…