Senior Scientist

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

We are looking for a highly motivated and self-driven professional to join our Cell Therapy Analytical Development (CTAD) department as a Senior Scientist
. The successful candidate will play a crucial role in developing and troubleshooting LC-MS assays to advance gene-edited cell therapy development deliverables.

The highly experienced assay developer will independently develop and execute LC-MS methods to support oligonucleotide process development and characterization, as well as the characterization of autologous and allogenic cell therapy products which are undergoing clinical trials. The Senior Scientist will design and analyze experiments with minimal supervision, leading to the development of robust LC-MS methods.

The Senior Scientist should possess significant hands‑on experience with LC-MS instrumentation and method development, demonstrate capability in collaborating with other groups, such as discovery research, product sciences, and process development. The ideal candidate will be passionate about developing novel medicines, thrive in an intellectually challenging environment, and enjoy collaborating with a team of like‑minded Scientists. This is a lab‑based position, with the level commensurate with experience.

• Act as a subject matter expert to design, develop, optimize, and standardize robust physiochemical methods—including LC, LC‑MS, CE, SEC/AEX‑MALS, preparative LC‑MS—for sample quality control and the characterization of oligonucleotides and proteins.
• Maintain and troubleshoot instrumentation (e.g., UPLC, LC‑MS, CE, MALS, LC‑MS) to ensure high performance, reliability, and minimal downtime in support of critical workflows.
• Maintain meticulous laboratory notebooks and manage routine sample analysis requests.
• Present scientific results and observations to colleagues at cross‑functional meetings, management, and at meetings with external partners.
• Author, review and approve technical documents, including methods, protocols, reports, and regulatory submissions.
• Good knowledge of cGMP and ICH/FDA/EMEA guidance.
• Complete regulatory, site, and department training requirements on a timely basis.

• A PhD with 3+ (BS with 10+) years of experience in pharmaceutical research, development, or related industry experience.
• Expert in HPLC and LC‑MS instrumentation from multiple vendors (e.g. Vanquish, Waters, Orbi Trap, Q‑Exactive), including setup, operating, troubleshooting and maintaining (i.e. vent and clean) as well as method development.
• Proficient in software such as Empower, Xcalibur, Chromeleon, Biopharma finder, Protein metrics etc.
• Strong background and experience in separations sciences, including but not limited to SEC, RP, IEX, HILIC and CE.
• Expert in developing LC‑MS and LC‑MS/MS methods for large biomolecules (e.g., mAb, ADC, proteins) including Intact mass, reduced mass, peptide mapping, and glycan mapping.
• Lead the development of new LC‑MS and LC‑MS/MS analytical methods for the characterization of nucleic acid‑based compounds: oligonucleotides, RNA and DNA‑based modalities.
• Ability to work effectively in a collaborative team setting and in a rapidly changing environment with frequent changes in priorities, which require strong organizational skills.
• Strong written and oral…