Research Scientist​/Engr

Field of research:

Protein engineering, synthetic biology, and biochemical tool development with emphasis on optogenetically controlled RNA/DNA polymerases, programmable nucleic-acid writing, and in vitro assay systems for polymerase activity, specificity, and error control.

To build and execute the experimental pipeline for engineering and characterizing light-responsive RNA polymerase systems. The position will support molecular cloning, protein production, and cell-free functional assays needed to generate sponsor-facing milestones and publications on optogenetic polymerase control, sequence-programmed RNA synthesis, and related protein-sensor technologies.

• Molecular cloning and construct generation – 25%
• Protein expression, purification, and QC – 20%
• In vitro functional assay development and execution – 25%
• Optogenetic characterization and readout integration – 15%
• Sequencing sample preparation and data/QC handoff – 10%
• Project support, documentation, and collaboration – 5%

This position is eligible for H-1B sponsorship.

Bachelor's Degree in Biochemistry, molecular biology, bioengineering, chem biol, or related field and one year of relevant experience laboratory research.

Equivalent education and/or experience may substitute for minimum qualifications except when there are legal requirements, such as a license, certification, and/or registration.

• Molecular cloning: PCR, Gibson/Golden Gate assembly, mutagenesis, bacterial transformation, plasmid preparation, and sequence verification.
• Protein production: bacterial expression, affinity purification, chromatography/FPLC workflows, and protein QC.
• Biochemical assays: experience with enzyme assays, transcription assays, fluorescence-based readouts, or related in vitro functional measurements.
• research assistantships/internships acceptable, strong hands-on

• Experience with cell-free transcription or nucleic-acid enzyme assays.
• Experience using modified nucleotides (e.g., fluorescent, biotinylated, or otherwise chemically functionalized substrates).
• Experience with optogenetic proteins, light-controlled assays, or photochemistry/fluorescence instrumentation.
• Sequencing library preparation or sample-prep familiarity for assay readouts.
• Experience with protein binders, display/selections, or protein-sensor engineering.
• Basic computational comfort for organizing data, plotting results, and working with standard lab analysis tools.
• Data quality and documentation: careful experimental record-keeping, sample tracking, and SOP development.
• Communication and teamwork: ability to summarize results clearly and work closely with the PI and collaborators.

$56,448.00 annual

$58,008.00 annual

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For information about benefits for this position, visit https://(Use the "Apply for this Job" box below)./

First Shift (United States of America)

This is a regular position

100.00%

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