Research Associate in Host Compatibility and in Vitro Biological Models

Job description:

We have an exciting opportunity to join the Mechanisms of Health & Disease research group within the School of Clinical Dentistry. The role is part of a major new externally funded interdisciplinary programme led by Dr Thomas Paterson, bringing together bioengineering, microbiology, neuroscience and translational neurotechnology.

The programme will explore whether engineered fungal networks can be developed as controllable bioelectronic interface materials. Current neural-interface technologies remain limited by trade-offs between surgical invasiveness, tissue compatibility, spatial coverage and long-term function. Fungal networks offer a distinctive biological platform: soft, three-dimensional structures that can be grown, modified and tested as part of future bioelectronic interface systems.

You will contribute to an ambitious research programme developing candidate fungal biointerfaces and evaluating them against clear safety, control and functional criteria as part of a large multidisciplinary team.

You will develop and apply in vitro and ex vivo biological models to test how candidate fungal materials interact with neural, glial, immune and barrier-relevant systems. The role will focus on host compatibility, inflammation, immune clearance, secreted-factor effects, neural-cell health and BBB/neurovascular model development. You will help determine whether engineered fungal candidates can coexist with biological systems without unacceptable toxicity, damaging inflammation, neural dysfunction or barrier disruption.

This role would suit a candidate with expertise in mammalian cell culture, neural or glial models, immunological assays, microscopy, tissue models, organoids, BBB/endothelial models or related in vitro systems. Experience with in vivo or ex vivo models would be useful, but the main requirement is strong hands-on experience with biological assays and quantitative readouts.

You will work closely with colleagues in fungal engineering, bioelectronic interface testing and in vivo proof-of-concept work. You will contribute to assay development, candidate screening, data analysis, milestone reporting, publications and the development of biological safety and compatibility readouts for the programme.

The University of Sheffield is a remarkable place to work. Our people are at the heart of everything we do. Their diverse backgrounds, abilities and beliefs make Sheffield a world-class university.

We offer a fantastic range of benefits including a highly competitive annual leave entitlement (with the ability to purchase more), a generous pension scheme, flexible working opportunities, a commitment to your development and wellbeing, a wide range of retail discounts, and much more.

Find out more at  and join us to become part of something special.

We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.