Synthetic Organic Chemist​/Medicinal Chemist, ADC

ABOUT CALLIO THERAPEUTICS

Headquartered in Seattle and Singapore, Callio Therapeutics is focused on realizing the promise of multi-payload antibody-drug conjugates (ADCs) to transform cancer patient outcomes. Significantly backed by the industry’s top investors, the company is developing next-generation, multi-payload ADCs that feature differentiated payload and linker technologies to maximize therapeutic benefit by enabling targeted delivery of multi agents to tumor cells. Callio Therapeutics is focused on driving its HER2-targeted dual-payload ADC to the clinic, gathering key clinical data, and progressing its pipeline assets.

ABOUT THE ROLE

We are looking for a Synthetic Organic Chemist/Medicinal Chemist in ADC Chemistry who will work closely with Antibody-Drug Conjugate team members as well as other cross-functional and external parties, such as CROs. As a Synthetic Organic Chemist/Medicinal Chemist, you will support the design, making and assessment of linker-payload molecules in our ADCs.

KEY RESPONSIBILITIES

• Participate in the design of molecules, including the identification of synthetic and other potential risks and their mitigations
• Conduct desk research into molecules and moieties, their properties and impact on ADC profile
• Prepare reports and other documents on synthetic routes, molecule synthesis, and molecule assessment, with attention-to-detail and data integrity
• Support administrative and finance activities, including raising and tracking of purchase requests, invoices and budgets
• Support molecule inventory & supply management, including maintaining of inventories, shipments and supply for ADC manufacture and other activities
• Support team management activities, including maintaining of activity trackers and dashboards to facilitate team and cross-functional collaboration

QUALIFICATIONS

Education & experience: Minimum qualifications:
PhD in organic/medicinal chemistry (preferred), alternatively a Masters degree in organic/medicinal chemistry with a minimum of 6 years, predominantly in industry/CRO setting

Skills:

• Expertise in the design of pharmaceutical molecules and their synthetic routes
• Experience in managing administrative activities of a chemistry R&D group, including the tracking of timelines/budgets/activities
• Experience in preparing reports/experimental write-ups/data summaries
• Experience working with external parties, such as CROs
• Experience in chemistry data analysis (HPLC, LC-MS, 1D/2D NMR, etc.)
• Proficiency with Chem Draw and standard productivity software
• Familiarity with medicinal chemistry and pharmacology (PK/PD) concepts in oncology as it relates to the design, assessment and iteration of a synthetic campaign
• Interest and understanding of the current trends and potential challenges in ADC linker-payload synthesis
• Strong written/oral communication and cross-functional collaboration skills
• Strong attention-to-detail and ability to quality check data sets

WHAT CALLIO THERAPEUTICS OFFERS

• Competitive compensation and comprehensive benefits package
• Opportunity to work in a dynamic, innovative, and collaborative environment
• Significantly contribute to potentially groundbreaking therapies for cancer patients