Scientist, Laboratory of Precision Disease Therapeutics; GIS

Scientist, Laboratory of Precision Disease Therapeutics (GIS)

Join A
* STAR - Agency for Science, Technology and Research as a Scientist, Laboratory of Precision Disease Therapeutics (GIS).

We seek a PhD‑trained scientist with expertise in early drug discovery for metabolic diseases, with several years of experience (ASO/siRNA therapeutic modality is preferred), target validation, and MASH research. Demonstrated ability to lead and execute discovery projects in both in‑house and CRO‑based settings, ensuring high‑quality data delivery and efficient project progression.

• Drug Discovery Expertise:
  Strong track record in early discovery, from target identification to validation, hit‑to‑lead and preclinical assessment.
• RNA Therapeutics (preferred):
  Hands‑on expertise with ASO and siRNA platforms, including design, in‑vitro/in‑vivo validation, and optimization for metabolic disease applications.
• Target Validation & Disease Biology:
  Experienced in establishing mechanistic links between targets and disease biology, with emphasis on MASH and metabolic disorders.
• Working with CROs:
  Effective in managing CRO collaborations, ensuring study design quality, data integrity, and timely execution of in‑vitro/in‑vivo experiments.
• Analytical & Critical Thinking:
  Skilled in data interpretation, decision‑making, and problem‑solving, enabling robust conclusions and informed go/no‑go project decisions.
• In Vitro & In Vivo Models:
  Proficient in cellular assays, screening compounds, critical assay flow scheme design, rodent disease models, and translational PD marker strategies relevant to disease.
• Cross‑functional
  
  Collaboration:
  
  Experience working closely with medicinal chemistry, pharmacology, and safety and toxicology teams to advance therapeutic candidates.
• Scientific Communication:
  Strong publication record, conference presentations, and ability to translate complex science for diverse stakeholders.

• PhD degree in a relevant field (e.g., biology, biochemistry, etc.).
• Experience in data collection, management, and analysis using software such as SPSS, R, or Python.
• Proficient in conducting literature reviews and synthesizing research findings.
• Excellent organizational and time‑management skills, with the ability to work on multiple projects simultaneously.
• Effective written and verbal communication skills, including the ability to present research findings.
• Attention to detail and commitment to maintaining data accuracy and confidentiality.

• Resume
• Contacts of minimum two referees
• A brief statement explaining research achievements (1 to 2 pages)

We regret that only shortlisted candidates will be notified.

The Genome Institute of Singapore (GIS, A
* STAR) is the national flagship program for genomic science in Singapore. GIS is located within Biopolis, the biomedical research hub of Singapore, which houses research institutes, biotech startups and international pharmaceutical corporations.

The applicant will have the opportunity to interact with scientists, informaticians, clinicians, engineers and other professionals from all over the world in a vibrant, intellectually stimulating and scientifically curious setting.

Singapore is a city‑state with one of the highest standards of living in the world, seeking to become an international hub for the biomedical sciences. It is a vibrant, tropical city with rich Asian heritage and modern style of living, an ideal gateway to explore Asia, providing a unique experience and an excellent quality of life.

More information about Prof. Ng Huck Hui’s lab, including recent publications, can be found online: https://(Use the "Apply for this Job" box below). (link removed for brevity).