Scientist​/Senior Scientist, Computational Biology

Location: Singapore
Employment Type: Full-time, Permanent
Relocation: International candidates welcomed

We are partnering with a major Singapore-based biomedical research and therapeutics organisation that is building an ambitious, highly translational drug discovery platform focused on the next generation of nucleic acid medicines.

As part of continued investment into its cardiovascular and metabolic disease portfolio, the organisation is seeking an experienced Scientist / Senior Scientist in Computational Biology and Target Discovery.

This is not a traditional bioinformatics support position. The successful scientist will play a central role in identifying, prioritising and validating novel therapeutic targets, integrating human genetics, multi-omics and disease biology to determine which targets should progress into experimental drug discovery.

The focus will be on MASH, obesity and related cardiometabolic diseases, with an emphasis on identifying targets suitable for therapeutic modulation using siRNA, ASO and other nucleic acid approaches.

• Identify and prioritise novel therapeutic targets across MASH, obesity and broader metabolic disease.
• Integrate human genetics, real-world evidence and multi-omics data to build compelling target hypotheses.
• Apply evidence from GWAS, rare variant analysis, transcriptomics, proteomics, metabolomics and lipidomics to target discovery.
• Translate complex computational findings into clear biological hypotheses and actionable drug discovery decisions.
• Investigate disease-relevant pathways across liver, adipose tissue and muscle biology, identifying opportunities for therapeutic intervention.
• Develop structured approaches for evaluating target confidence, biological rationale, clinical relevance and druggability.
• Assess whether targets are suitable for intervention using siRNA, ASO or related RNA-based modalities, including consideration of tissue accessibility and delivery.
• Work closely with computational scientists, biologists and pharmacologists to build fit-for-purpose target validation strategies.
• Connect target biology with relevant translational biomarkers and clinical endpoints.
• Drive clear go / no-go recommendations for individual targets and help build a continually evolving pipeline of opportunities.
• Provide scientific leadership across cross-functional target discovery activities and communicate complex computational evidence to both computational and non-computational colleagues.

The successful candidate will ideally bring:

• A PhD in Biology, Genetics, Genomics, Bioinformatics, Pharmacology, Computational Biology or a related discipline.
• Approximately 5+ years’ relevant experience for Scientist level and 10+ years for Senior Scientist level, ideally within pharmaceutical or biotechnology drug discovery.
• Strong experience in therapeutic target discovery, human genetics and/or translational disease biology.
• Deep understanding of metabolic disease biology, ideally including MASH, obesity or related cardiometabolic disorders.
• Proven experience integrating and interpreting large-scale human genetics and multi-omics datasets.
• Strong understanding of the difference between correlative biological signals and evidence supporting causal disease relationships.
• Experience identifying, prioritising and progressing novel targets through early drug discovery.
• Proficiency in Python and/or R for analysis, visualisation and development of computational frameworks.
• Ability to work effectively with specialist bioinformatics teams while maintaining ownership of the biological and drug discovery question.
• Familiarity with siRNA, ASO or other nucleic acid therapeutics and an understanding of how target biology, tissue…