Senior Scientist - Lead Optimisation Unit

Chugai Pharmabody Research Pte. Ltd. ("CPR") was established in Singapore as a wholly-owned subsidiary of Chugai Pharmaceutical Co., Ltd (Chugai), a member of Roche group, in January 2012 and started operations on July 2, 2012. Located at Geneo in Singapore , it aims to generate new antibody drugs based on Chugai's proprietary antibody engineering technologies, such as recycling antibody®, sweeping antibody®, bispecific antibody, various Fc engineered antibodies, and other new antibody engineering technologies that are under development.

CPR is seeking a motivated Senior Scientist with demonstrated expertise in protein engineering and a strong passion for medical science. This position offers the opportunity to contribute to the discovery and development of innovative drugs designed to address unmet medical needs.

• Optimize Lead Candidates:
  Drive humanization, affinity optimization, and the optimization of physicochemical properties to significantly improve the pharmacokinetics (PK), safety and efficacy of therapeutic antibodies.
• Engineer Antibody Formats:
  Design, construct, and evaluate diverse antibody formats including bispecifics antibodies, antibody fragments, antibody-drug conjugates (ADCs), and fusion proteins, to achieve optimal structural stability, develop ability, and precise therapeutic functions.
• Pioneer New Antibody Technologies:
  Lead the research and development of next-generation antibody platforms, novel discovery methodologies, and proprietary engineering technologies to expand the therapeutic pipeline and address complex disease targets.
• Drive
  
  Cross-Functional Collaboration:
  
  Partner closely with diverse scientific departments such as target biology, pharmacology, and manufacturing to advance engineered therapeutics from discovery through development.

• PhD in Biomedical Science, Biochemistry, Chemical Biology, Biotechnology, Information Science, or a related discipline.
• Demonstrated technical expertise in areas such as molecular biology, cell biology, protein chemistry, or protein engineering, evidenced by research projects, presentations, patents, and/or peer-reviewed publications.
• Demonstrated strong expertise in at least one of the following areas:
  • Protein and/or antibody engineering, including rational or random mutagenesis approaches.
  • Structural and molecular biology for protein structure and function investigation.
  • Structural modelling and/or machine learning.
  • Protein biochemistry, including protein expression, purification, and characterisation.
• Excellent organisational skills with the ability to manage and interpret large datasets.
• Strong communication and collaboration skills, with the ability to work effectively in cross-functional and multidisciplinary teams.
• Good command of spoken and written English.
• Self-motivated team player with the capability of managing multiple priorities in a dynamic research environment.

• Prior work experience in antibody drug discovery.
• Knowledge of high-throughput systems, automation, and/or general scripting languages.
• Knowledge of cell biology, biophysics or immunology.

For more information regarding our Company, you may refer to our website at:

We regret that only short-listed candidates will be notified