Scientist - Immune Reset

We are looking for a Scientist who is passionate about immune‑cell biology, T‑cell engagers, and advancing next‑generation immunotherapies to join our Immune Reset team, based in Slough, UK.

About The Role

In this role, you will play a key part in progressing novel therapeutic molecules by designing, developing, and executing functional T‑cell engager assays using primary human immune cells. You will drive mechanistic studies, contribute expertise in molecular and structural biology, and collaborate across departments to inform molecular engineering strategies. This is an exciting opportunity to work at the interface of immunology, protein engineering, and translational science.

Who You’ll Work With

You will collaborate closely with immunologists, structural biologists, protein engineers, and cross‑functional project teams. You will also present findings in internal scientific forums and contribute to high‑quality scientific documentation. You will help guide the structural‑biology understanding of antibody–antigen interactions and partner with colleagues across discovery and translational functions.

What You’ll Do

• Design and execute functional T‑cell engager assays evaluating potency, specificity, and mechanism.
• Perform mechanistic studies investigating immune synapse formation and T‑cell activation pathways.
• Collaborate cross‑functionally to support structural‑biology interpretation and optimization strategies.
• Analyse complex immunological datasets and deliver actionable insights to project stakeholders.
• Troubleshoot technical assay challenges to drive consistency and high‑quality experimental outcomes.
• Present scientific results clearly during internal and cross‑functional scientific review meetings.
• Contribute to scientific reports, publications, and documentation supporting program advancement efforts.
• Isolate and characterize primary immune cell subsets using FACS or MACS‑based approaches.
• Ensure compliance with Human Tissue Act (HTA) requirements and maintain accurate scientific records.
• Uphold health, safety, and SOP‑driven standards across all laboratory and documentation activities.

Interested? For this role we’re looking for:

• Demonstrated expertise in evaluating T‑cell engagers using functional and phenotyping immune assays.
• Hands‑on experience working with primary immune cells, including isolation via FACS or MACS.
• Strong background in multi‑parameter flow cytometry, immune profiling, and panel design.
• Understanding of antibody engineering, structure–function principles, and relevant biophysical concepts.
• Proficiency with analysis tools such as Flow Jo, Graph Pad Prism, Excel, and R.
• Excellent communication, teamwork, and documentation practices with a strong compliance record under HTA guidelines.

Are you ready to ‘go beyond’ to create value and make your mark for patients? If this sounds like you, then we would love to hear from you!

About Us

UCB is a global biopharmaceutical company, focusing on neurology and immunology. We are over 9.000 people in all four corners of the globe, inspired by patients and driven by science.

Why work with us?

At UCB, we don’t just complete tasks, we create value. We aren’t afraid to push forward, collaborate, and innovate to make our mark for patients. We have a caring, supportive culture where everyone feels included, respected, and has equal opportunities to do their best work. We ‘go beyond’ to create value for our patients, and always with a human focus, whether that’s on our patients, our employees, or our planet.

Working for us, you will discover a place where you can grow, and have the freedom to carve your own career path to achieve your full potential.

At UCB, we’ve embraced a hybrid-first approach to work, bringing teams together in local hubs to foster collaborative curiosity. Unless expressly stated in the description or precluded by the nature of the position, roles are hybrid with 40% of your time spent in the office.

UCB is an equal opportunity employer. All employment decisions will be made without regard to any characteristic protected by applicable laws.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on EMEA-Rea Please note should your enquiry not relate to adjustments; we will not be able to support you through this channel.