Oligo Chemistry and Biochemistry Co-op

Position: Oligo Chemistry and Biochemistry Co-op (Spring 2027)
Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology.

Our diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing our versatile RNA medicines platform.  Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Scope:
Wave Life Sciences USA seeks highly motivated co-op students to join its team of scientists in Cambridge, Massachusetts.  The co-op student will gain exposure to areas of oligonucleotide chemistry, and biochemistry/bioanalytical chemistry. Co-ops will be trained in a variety of laboratory techniques and instrumentation, making this an excellent learning opportunity.  This is an ideal position for any student, including those looking for their first co-op, with strong organizational skills and attention to detail who thrives in a team-oriented, fast-paced and cross-disciplinary biotech environment.  

Organic chemistry or biochemistry laboratory experience is preferred. Responsibilities Assist in the upstream and downstream biochemical/bioanalytical and biological analysis of oligonucleotides

Preparation of reagents and buffers for biochemical/bioanalytical and biological experiments by measuring the weight of organic compounds and the volume of solutions

Preparation of buffer solutions of specified molarity for Liquid Chromatography (LC) analysis of oligonucleotides

Assist in the operation of Liquid Chromatography Mass Spectrometry (LCMS) system and be able to learn and work on the system

Assist in the physicochemical experiments (thermal denaturing experiment etc.) of oligonucleotides

Maintain a detailed report of experimental procedures and findings in electronic lab notebooks

Use of pH meter, Nanodrop to record data

Use of MS Excel is preferred

Skills and Competencies Present experimental data in team meetings

Eager to learn about instrumentation and work with new technology

Following the lab safety protocols including use of PPEsPay Range Disclosure Statement $24—$30 USDThe range provided is based on what we believe is a reasonable estimate for the annual base salary pay range for this position at the time of posting. Actual annual base salary will vary based on several factors including, but not limited to, relevant skills, experience, qualifications, position criticality, and internal equity.  

This position is eligible for a discretionary annual bonus and discretionary stock-based long-term incentives.  In addition to compensation, Wave offers a comprehensive and competitive range of benefits designed to support our employees’ and their families physical and financial health and overall well-being. These include, but are not limited to, company-sponsored medical, dental, vision, life, long and short-term disability insurances, generous paid time off (including a week-long company shutdown in the Summer and the Winter), 401K participation with matching contributions, and Employee Stock Purchase Program.

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and…