Director, Financial Reporting & Technical Accounting

insitro is a physical AI company dedicated to unlocking causal human biology and accelerating the delivery of better medicines to patients. Our unique Virtual Human™ platform identifies novel, high-impact genetic intervention points, which our TherML™ platform translates into therapeutics, whether small molecules, biologics, or oligos. With multiple programs in metabolic disease and neuroscience advancing toward the clinic, we are at a pivotal inflection point.

insitro is looking for an Director, Financial Reporting & Technical Accounting
, with level set by experience, to be the company’s technical accounting expert and the owner of its financial reporting. In this senior individual contributor role, you will lead the year-end audit and financial statements, account for insitro’s most complex transactions, including pharma collaboration revenue, equity financings, and stock-based compensation modifications, and own the 409A valuation, international compliance, and accounting policy.

This is also a chance to help build the function: as insitro grows, you will take on ownership of SOX and SEC reporting and help expand the team, playing a central role in building a public-company-ready finance organization, with a clear path to grow in level and scope as the function expands.

This position is based at our South San Francisco headquarters, reports to the SVP, Accounting & Financial Operations
, and works onsite three days per week as part of our in-person hybrid model.

• Own the Financial Statements:
  Direct the annual audit and financial statement process, preparing US GAAP financial statements and footnote disclosures that are accurate, timely, and fully supported
• Run the Audit:
  Serve as the primary point of contact for our external auditors, leading audit planning, the PBC list, tie-outs, disclosure checklists, and resolution of audit comments
• Lead the Disclosure Committee:
  Own and lead the Disclosure Committee, including setting the agenda, running the meetings, gathering and assessing potential disclosure items from across the company, and documenting conclusions
• Prepare Executive and Board Materials:
  Prepare and update financial reporting and accounting content for Executive Leadership Team and Board of Directors materials and support the monthly reporting package and ad hoc investor requests

• Lead Technical Accounting:
  Lead research and author memos on complex and non-routine transactions, including ASC 606 / ASC 808 collaboration and partnership revenue, ASC 842 leases, and equity and financing instruments
• Account for the Pipeline:
  Evaluate the accounting and disclosures for preclinical and clinical activities as our programs advance toward the clinic, including R&D and clinical trial accrual methodologies for CRO and CDMO arrangements
• Shape Deals Early:
  Partner with Corporate Development, Legal, and Strategic Finance on partnership agreements, financings, and other transactions so accounting implications are assessed before terms are finalized
• Leverage Advisors:
  Serve as the primary liaison to our third-party tax advisor, communicating the tax implications of deals, financial results, and other transactions, and overseeing the tax provision, tax returns, R&D credit study, Section 382 analysis, and equity tax considerations for grants outside the US
• Set the Policy:
  Develop, document, and maintain US GAAP accounting policies; monitor FASB developments and lead the adoption of new standards

• Own Stock-Based Compensation Accounting:
  Own ASC 718 accounting and reporting, including expense recognition, award modifications, forfeitures, roll-forwards, and related…