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Senior Medical Director; Neurology & Early Development

Job in South San Francisco, San Mateo County, California, 94083, USA
Listing for: Enigma Search
Full Time position
Listed on 2025-12-27
Job specializations:
  • Dental / Dentistry
    Healthcare Consultant
Job Description & How to Apply Below
Position: Senior Medical Director (Neurology & Early Development)

Senior Medical Director (Neurology & Early Development)

Base pay range: $/yr - $/yr

Additional compensation: Annual Bonus

Our client is seeking a Medical Director or Senior Medical Director to lead their Neurological and Neuropsychiatric clinical portfolio.

This is a high-impact role reporting directly to the Head of Clinical Sciences. You will be the clinical architect for programs moving from preclinical discovery into human ‘Proof-of-Mechanism’ and ‘Proof-of-Concept’ trials.

The Impact You Will Make
  • Strategic Leadership: Lead high-performing cross-functional teams to translate preclinical data into robust human clinical strategies and biomarker development.
  • Experimental Medicine: Design and execute innovative ‘Phase 0’ through Phase 2 studies to demonstrate proof-of-mechanism for novel targets in the neuropsychiatric space.
  • Collaborative Discovery: Act as a key interface between research and drug development, working closely with discovery scientists and external partners to shape disease indication strategies.
  • Clinical Expertise: Utilize your medical background to guide the development of preclinical models and ensure they align with human clinical needs.
  • Regulatory & Scientific Content: Author and provide expert medical oversight for protocols, Investigator Brochures (IBs), Clinical Study Reports (CSRs), and regulatory submissions.
Who You Are
  • Physician-Scientist: You hold an M.D. or an M.D./Ph.D. with a deep scientific mindset.
  • Neurology Expert: Board certification or eligibility in Neurology or Pediatric Neurology is highly preferred.
  • Proven Industry Veteran: You have 5+ years of translational or clinical drug development experience within biotech, pharma, or a top-tier academic research setting.
  • Early Phase Specialist: You possess direct experience or a deep working knowledge of early clinical trial methodology (Phase 0, 1, and
    2).
  • Collaborative Leader: You excel in a matrixed environment, possessing the ability to lead through influence and bring out the best in cross-functional teams.
Why This Role?

This is not a traditional ‘late-stage’ medical monitoring role. This is a position for a scientist-clinician who wants to be at the forefront of Early Development (Translational), working on novel targets that have the potential to redefine how we treat neurological diseases.

Seniority Level
  • Director
Employment Type
  • Full-time
Job Function
  • Research and Science
Benefits
  • Medical insurance
  • Vision insurance
  • 401(k)
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Position Requirements
10+ Years work experience
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