Senior Principal Mechanical Engineer, Site Services

The Position

As a Senior Principal Mechanical Engineer at Genentech, you’ll have the unique opportunity to lead the charge in designing and upgrading advanced mechanical systems for a dynamic and evolving portfolio of facilities spanning over 6 million square feet across South San Francisco, Dixon, and beyond. Acting as a technical authority, you’ll drive innovative and efficient solutions for critical mechanical infrastructure, utilities, and HVAC systems that underpin Genentech’s cutting‑edge operations.

Collaborating with cross‑functional teams and industry leaders, you’ll play a strategic role in shaping site standards, ensuring alignment with emerging technologies, regulatory requirements, and corporate excellence. If you’re a seasoned engineer with a passion for innovation, collaboration, and pushing industry boundaries, this pivotal role offers the chance to make a lasting impact across a globally recognized organization.

The responsibilities for this position may include, but are not limited to:

• Under the direction of the Director of Design Engineering, the Design Engineering Senior Principal Mechanical Engineer provides technical leadership and accountability for mechanical engineering designs on capital projects and engineering services done at the South San Francisco, Dixon sites and other sites as requested.
• This role engages actively in the design and planning of upgrades to critical mechanical infrastructure, utilities and facility HVAC systems across a portfolio of 50+ buildings / 6M square feet of space.
• This role is a respected industry expert and engages with the Roche internal and industry external network to learn, influence and collaborate on new technologies, best practices and standards, bringing this knowledge and expertise to bear so that project designs provide safe, efficient and reliable operations to Genentech customers.

• The primary area of focus for this role will be supporting the execution of a portfolio of projects with technical input and technical coordination in the mechanical engineering area, including design guidance on HVAC, plumbing, fire protection, building controls, automation and energy management.
• The Senior Principal Mechanical Engineer will be assigned 2–3 large scale projects ($10M and above) and a portfolio of approximately 20 projects at a time (ranging in size from $50K to $10M each). They will attend key design meetings and provide design input and technical options analysis.
• The projects will be executed by multi-disciplinary teams, and this role will need to align, coordinate input and influence key customers (R&D, Commercial, Pharmaceutical Technical Operations) and stakeholders (Site Operations, SHE and Security) on project designs.

• The Senior Principal Mechanical Engineer will also provide management and oversight of other Mechanical SMEs brought in as required to manage influx of mechanical related work.
• A key function of this role will also be to align the many project designs to Roche / Genentech and site specific standards, and to coordinate the scope done on these many small projects into a comprehensive strategy to address needs in this technical area across the site.

• SSF Design and Construction executes the design work on portfolio (less than $10M) projects using the services of three alliance engineering firms, each of whom has an assigned mechanical engineering lead. The role will lead a mechanical engineering design sub‑team including the representatives of each of these three firms, along with representatives of Site Operations, Environment, Health and Safety (EH&S), and others.
• As defined by project needs, this team will be tasked with developing strategies for upgrading deficient areas of the campus through the project portfolio.
• This team may also engage in the development and review of design standards.

• This role will be responsible for developing site specific mechanical design standards. Such standards will be based on Roche/Genentech…