Associate Director, Toxicology

Associate Director, Toxicology page is loaded## Associate Director, Toxicology locations:
South San Francisco time type:
Full time posted on:
Posted 30+ Days Agojob requisition :
R-1402

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

The Associate Director, Principal Scientist, Toxicology will play a critical role in driving the nonclinical safety assessment of small and large molecule therapeutics within Denali’s pipeline. This position involves conducting and managing toxicology studies, analyzing and interpreting safety data, and collaborating with cross-functional teams to advance drug candidates through various stages of development. This role serves as a functional leader for the Toxicology team and includes people leadership accountability for one or more Toxicologists.

Key Accountabilities/Core

Job Responsibilities:

Nonclinical Toxicology Support:
* Design and implement nonclinical toxicology programs and strategies to evaluate the safety of Denali's therapeutic candidates.
* Conduct and oversee non-GLP and GLP toxicology studies, ensuring adherence to regulatory standards.

Data Analysis and Reporting:
* Analyze, interpret, and summarize toxicology data to support safety evaluations.
* Prepare and present safety data to internal project teams and senior management, contributing to informed decision-making.

Regulatory Support:
* Assist in the preparation and authoring of regulatory documents related to nonclinical safety assessments.
* Ensure compliance with relevant regulatory guidelines and standards throughout all stages of toxicology studies.

Collaboration and Cross-Functional Work:
* Work closely with colleagues in Research and Development, providing toxicology expertise to support cross-functional project teams.
* Participate in project meetings, offering insights and recommendations to advance safety assessment strategies.

Investigative Efforts:
* Support investigative efforts into mechanisms of toxicity and contribute to the development of safer therapeutic candidates.
* Assist in developing and implementing de-risking strategies for drug discovery and development projects.

People Leadership:
* Lead direct report(s) through annual goal setting, growth planning, adherence to company policies, maintain training compliance and provide ongoing feedback on growth, development and areas of improvement.

Qualifications/

Skills:

* PhD OR Advanced Degree in Toxicology, Biology, Pharmacology or related scientific discipline.
* At or near 7 plus years of relevant work experience inclusive of postdoctoral work; OR MS with 10+ years of relevant work experience.
* Experience with biologics and oligonucleotides preferred
* Strong scientific background and scientific aptitude
* Excellent critical thinking and scientific skills
* Ability to work effectively and collaboratively on cross-functional projects teams, and demonstrated can-do attitude
* Ability to work in a fast-paced environment
* Excellent oral, presentation, and written communication skills

Salary Range: $ to $ .  Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at  compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.“Life

at Denali” is a living reflection of our values: trust, unity, grit and growth. These are not just words we share—they shape how we show up, collaborate and push boundaries together. From the lab to the community, across functions and milestones, our culture thrives on shared purpose and relentless pursuit.
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