Scientific Associate Director - PKDM; Molecule ADME

Scientific Associate Director - PKDM (Small Molecule ADME) page is loaded## Scientific Associate Director - PKDM (Small Molecule ADME) remote type:
On Site locations:
US - California - South San Francisco:
US - California - Thousand Oakstime type:
Full time posted on:
Posted Yesterday job requisition :
R-218694##
** Career Category
** Scientific## ##
** Job Description**## Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
** Scientific Associate Director - PKDM (Small Molecule ADME)**##
** What you will do
** Let’s do this. Let’s change the world. In this vital and exciting role you will oversee biotransformation activities and can serve as a project team representative focused on small molecule (SM) programs. You will characterize the absorption, distribution, metabolism, excretion (ADME) and pharmacokinetic (PK) properties of SM therapeutic drug candidates to achieve their full pharmacological potential. In this role, your core responsibilities include:
* Serving as a subject matter expert of small molecule biotransformation and leading biotransformation activities to support the programs and develop strategies to reduce/mitigate risks due to metabolism.
* Leveraging current biotransformation knowledge of metabolism as well as developing/implementing novel tools to efficiently support biotransformation related activities.
* Serving as a functional PKDM project team representative (PTR) and subject matter expert on the ADME/PK of small molecule therapeutics, collaborating with scientists across our PKDM scientific community
* Leveraging specialized ADME/PK skills such as in vitro ADME, in vivo ADME, biotransformation, PK/PD, or physiologically-based pharmacokinetic modeling (PBPK) to impact project progression and decision-making
* Planning and executing mechanistic ADME/PK analyses to integrate knowledge of drug design parameters, disease pharmacology, physiology, pharmacokinetics and pharmacodynamics to optimize dose selection and preclinical study designs.
* Contributing to the analysis of pre-clinical ADME and PK data for IND and NDA filings and documenting these analyses in appropriate reports
* Building close relationships with partner functions and therapeutic areas##
** What we expect of you
** We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a subject matter expert with these qualifications.
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* Basic Qualifications:

** Doctorate degree PhD OR Pharm

D OR MD [and relevant post-doc where applicable] and 4 years of directly related experience## OrMaster’s degree and 7 years of directly related experience## Or Bachelor’s degree and 9 years of directly related experience
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* Preferred Qualifications:

*** PhD in Pharmacokinetics, Pharmaceutical Sciences, Engineering, or related fields with equivalent professional degrees and 10+ years of experience in the Biotechnology/Pharmaceutical Industry, consulting or post-doctoral training
* Candidate should have solid technical experience with the application of SM in vitro/in vivo ADME and pharmacokinetics fundamentals to drug discovery projects
* Ability to drive the progression of SM discovery and development within project teams
* Establish SM biotransformation and ADME workflows for PKDM scientists.
* Expertise with in vitro ADME, in…