Scientist, Research Scientist, Clinical Research

This range is provided by Neurona Therapeutics. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

$/yr - $/yr

Neurona Therapeutics is a clinical‑stage biotechnology company based in South San Francisco focused on the development of allogeneic cell‑based therapies for neurological diseases.

Neurona’s lead product candidate, NRTX‑1001, comprising GABAergic interneurons, offers a novel approach that is not tissue‑destructive for the potential treatment of drug‑resistant focal epilepsy. NRTX‑1001 is currently being studied for safety and efficacy in two ongoing open‑label multicenter, Phase 1/2 trials: NCT for drug‑resistant unilateral mesial temporal lobe epilepsy (MTLE), and NCT for drug‑resistant bilateral MTLE. Neurona plans to initiate the Phase 3 EPIC (EPIlepsy Cell Therapy) trial in 2H 2025.

The Phase 3 EPIC trial will be for patients with drug‑resistant unilateral MTLE with mesial temporal sclerosis.

• Perform cell culture experiments using directed neuronal differentiation from human PSCs
• Collaborate with teammates to develop and optimize next‑generation cell products with enhanced characteristics (composition, potency, maturation)
• Develop cell‑based assays to test and validate hypotheses for mechanism of action studies
• Apply gene editing, viral gene delivery, and/or chemical screens to develop neuronal cell products
• Characterise cell products (immunocytochemistry, Flow cytometry, RT‑qPCR, RNA sequencing assays)
• Design, plan and execute experiments using single‑cell RNA sequencing pipeline
• Conduct fluorescence and/or magnetic‑activated cell sorting experiments
• Collaborate with multidisciplinary teams from discovery, process, and preclinical departments
• Maintain detailed records, perform data analysis, and report results during team meetings
• Willing to work a limited number of hours overtime and/or on weekends

• PhD with up to 3 years of relevant experience or master’s degree with 6‑8 years of relevant experience in pluripotent stem cell biology, neuroscience or related field (molecular/cell/developmental biology)
• Hands‑on experience with sterile mammalian cell culture, human pluripotent stem cell (hIPSC/hESC) culture, in‑vitro differentiation and neuronal cell culture
• Expertise in histochemical techniques and microscopy
• Expertise in high‑content screening microscopy, creation of image analysis algorithms for both fixed samples and for live imaging
• Expertise in lab automation and in‑vitro assay miniaturization
• Experience in gene delivery, including viral transduction with LV/AAV
• Excellent analytical skills, critical thinking, and problem solving
• Superb organizational skills and attention to detail
• Willingness to learn, expand skill set and contribute to a highly dynamic start‑up environment
• Ability to deliver within fast‑paced timelines
• High integrity, excellent written, verbal and interpersonal communication skills
• Strong team player, able to work on teams and independently
• Proven scientific achievements evidenced by high‑impact publication record
• Able to take initiative to improve work processes, develop innovative scientific methodologies and approaches to enhance research productivity

• Knowledge in neuroscience and human developmental biology
• Experience in high‑content microscopy and multiparametric data analysis
• Experience in bioinformatics, coding, R, Python is a plus
• Experience in calcium imaging and/or multi‑electrode arrays is a plus

Entry level

Full‑time

Research, Analyst, and Information Technology