Senior Research Associate II, Medicinal Chemistry

Senior Research Associate II, Medicinal Chemistry

Apply for the Senior Research Associate II, Medicinal Chemistry role at Bio Space.

Join our innovative drug discovery team as a Senior Research Associate II. In this role, you’ll apply your expertise in organic and medicinal chemistry to synthesize, purify, and characterize novel molecules that could lead to breakthrough therapies. You’ll work hands‑on with cutting‑edge techniques and collaborate across functions to advance our research programs.

• Execute multistep syntheses of complex small molecules and characterize intermediates and final products.
• Propose new compounds for synthesis based on SAR and synthetic knowledge.
• Summarize and interpret results and present findings in research meetings.
• Learn new laboratory techniques, troubleshoot experiments, and ensure high-quality execution.
• Utilize scientific literature and databases (e.g., Sci Finder) to design efficient synthetic routes.
• Collaborate with scientists across functions to develop and optimize newly generated molecules.

• B.S./M.S. in Chemistry with at least 4 years of relevant experience in synthetic organic or medicinal chemistry.
• Demonstrated experience in organic synthesis, chromatographic purification, and compound characterization using modern analytical techniques (NMR, LCMS, HPLC, etc.).
• Strong organizational skills and attention to detail.
• A proactive, solution‑oriented approach and commitment to collaboration.
• Ability to learn and adapt in a fast‑paced environment.
• Excellent verbal and written communication skills.

Maze Therapeutics is a clinical‑stage biopharmaceutical company harnessing the power of human genetics to develop novel, small‑molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization.

The company’s pipeline is led by two wholly owned lead programs, MZE
829 and MZE
782, each of which represents a novel precision medicine‑based approach for chronic kidney disease. Maze is based in South San Francisco.

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work.

While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

• Further Together – Our path is paved with challenges, but with resilience and a team‑first mentality, we’ll achieve our mission.
• Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
• Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $120,000 – $147,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position‑based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job‑related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

Mid‑Senior level

Full‑time

Research, Analyst, and Information Technology

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