Scientist , Immunology

Scientist I

Location:

South San Francisco, CA

Position:
Full-Time

Gen Edit is a rapidly-growing, early-stage company that is developing a proprietary and novel delivery platform with the potential to transform genetic medicine. Our interdisciplinary team works together across chemistry, payload design, formulation, and screening and preclinical groups to develop the next generation of gene therapies. Gen Edit fosters an exciting and dynamic environment where we value impactful data and creative solutions to accelerate our progression from a platform technology to a pipeline of therapeutic candidates.

We are seeking talented and motivated individuals to join our team and are expanding across all functions within the organization. Join us in Brisbane, CA, to be at the forefront of the future of gene therapy.

We are seeking a talented and motivated Scientist to join our Immunology team and drive the development of genetic medicines for immune-based diseases utilizing our hydrophilic nanoparticle (HNP) technology. This individual will report to the Program Lead and will be responsible for assisting with planning and executing short and long-term R&D strategy for the Immune Program. She/he will be a key contributor to project and study design, method development, program strategy, and HNP and payload screening to identify lead therapeutic candidates that meet strict in vitro and in vivo target criteria for tissue and cell-specific delivery of nucleic acid payloads to achieve the desired immune modulating activity.

The ideal individual will have a strong background in cellular immunology, immune modulation and tolerance, vaccines, gene therapy, and rodent models of immune-based diseases. Individuals with industry experience as a key individual contributor on project teams and a successful track record of completed projects on time and teamwork are preferred. Position title will be commensurate with scope of responsibilities and years of relevant experience.

• Lab: Conceptualize and execute complex in vitro and in vivo immunology studies including study design, method development, independent data analysis, and technical problem solving. (75% bench work)
• Scientific leadership: Assist in goal setting and strategy, project and study planning, resource management, mentorship of junior staff, and hands-on study execution to ensure timely achievement of corporate milestones and goals. Function internally as a key opinion leader in matters related to immunology and tolerance.
• Supervisor: May manage Research Associate(s) depending on experience including: workflow organization, goal setting, assigning objectives, mentoring, performance evaluation, skills and career development.
• Collaboration and communication: Work cooperatively with peers and multidisciplinary teams in a highly matrixed lab environment, keep detailed and organized lab records, and present results at team, internal company, and external alliance meetings.

• Ph.D. or equivalent in Immunology or a related life science field.
• 1-2 years of biotech/pharma experience. Applicants with relevant postdoctoral experience in immune tolerance and autoimmune diseases will be considered.
• Broad and deep knowledge in immune response regulation and modulation at the cellular and molecular level.
• Direct experience in development, troubleshooting, and execution of in vitro immune based assays including primary immune cell culture and differentiation, immune cell phenotyping, and functional assays (e.g., flow cytometry, ELIspot, cytotoxic T cell assays, APC/T cell co-culture) is required.
• Deep understanding of the antigen presentation process, Treg, DC and/or macrophage biology, and immune modulation. Knowledge of tolerance, vaccine development and gene therapy/delivery a plus.
• Work authorization in the US is required.

• Primary immune cell culture of DC, monocyte, macrophage, and T cells including in vitro and ex vivo functional assays.
• Design and execution of in vivo studies to evaluate therapeutic drug candidates for safety and efficacy in mouse models of autoimmune and inflammatory diseases.
• Proficiency with comprehensive immune cell phenotyping by multicolor (12+) flow cytometry (Cytek Northern Lights, BD cytometers, Cyto Flex), ICC (Cytation), cytokine analyses (CBA, MSD), ELISA, ELISpot, andICS, and related assays.
• In vitro and in vivo screening of drug candidates, microplate cell assays, protein expression, cytotoxicity, fluorescent cell and tissue imaging, luminescence, BLI (IVIS), quantitative microscopy and image analysis.
• Preferred experience with molecular biology techniques including characterization of nucleic acid and protein therapeutic payloads.

• A highly professional, enthusiastic, self-starting and goal-focused scientist.
• Intellectually agile, curious, and able to thrive in a fast-paced, dynamic environment.
• Excels at technical innovation and creative problem solving,…