Scientist, Bioanalytical and Translational Sciences; PK, ADA, Biomarkers

Scientist, Bioanalytical and Translational Sciences(PK, ADA, Biomarkers)

Department: Translational Research

Position Summary:

TCG Labs–Soleil is seeking a highly motivated and detail-oriented Scientist to join our Bioanalytical/Translational Research team. This role is primarily laboratory-based (approximately 80%) and will focus on the design, development, and execution of bioanalytical assays to support clinical and non-clinical programs, including pharmacokinetics (PK), anti-drug antibody (ADA), and biomarker assessments. The position also includes vendor oversight (approximately 20%) for method development, transfer, and validation at external bioanalytical laboratories.

Key Responsibilities

• Assay Development & Execution (Lab-Focused)
• Design, develop, optimize, and qualify ligand binding assays (LBA) for:
• Immunogenicity (ADA)
• Biomarker detection (exploratory and translational)
• Perform non-clinical sample analysis to support discovery and development programs.
• Troubleshoot assay performance issues, implement improvements, and document method changes.
• Conduct critical reagent labeling (e.g., biotinylation, fluorophore conjugation) and manage reagent inventory.
• Maintain accurate and detailed records in electronic lab notebooks (ELNs) and ensure compliance with internal quality systems.
• Analyze and interpret data; present findings to project teams.
• Coordinate and oversee method development, transfer, and validation activities at external bioanalytical labs.
• Review protocols, reports, and data from CROs to ensure quality and compliance with regulatory expectations.
• Serve as a technical point of contact for troubleshooting and assay-related discussions with external partners.
• Cross-Functional Collaboration
• Work closely with Research, Nonclinical Development, Translational Sciences, and Clinical Development teams to align bioanalytical strategies with program goals.

Qualifications

Required:

• Degree in Biochemistry, Molecular Biology, Pharmacology, or related field:
• BS + 8 years, MS + 5 years, or PhD + 2 years of relevant hands-on industry experience in bioanalytical or immunoassay settings.
• Strong experience in ligand binding assays for PK, ADA, and biomarker applications.
• Proficiency with MSD (electrochemiluminescence) and ELISA platforms.
• Demonstrated ability to troubleshoot and optimize assay performance.
• Experience with non-clinical sample matrices (e.g., rodent, NHP plasma or serum).
• Expertise in reagent labeling and qualification (biotinylation, conjugation).
• Excellent documentation and organizational skills.

Preferred:

• Experience managing assays at external CROs is a plus
• Experience with automated immunoassay platforms (e.g., Gyrolab) is a plus
• Knowledge of regulatory bioanalytical guidelines (FDA, EMA).
• Familiarity with GLP or GxP-adjacent environments.

Company Overview

TCG Labs-Soleil, established in partnership with The Column Group , a science-focused venture capital firm, is pioneering a novel ‘venture capital-biotech’ model. Our core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases. This model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with our independent, evergreen R&D center led by a top-tier scientific team (Soleil).

Together, we create an integrated ecosystem that fosters the development of single-asset portfolio companies, strategically poised for transacting after clinical PoC.

TCG Labs-Soleil is an Equal Opportunity Employer. We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy (including childbirth and related conditions), national origin, ancestry, age, marital status, military or veteran status, sexual orientation, genetic information, physical or mental disability or medical condition as defined by applicable equal opportunity laws.

Any request for accommodation can be directed to  .

Benefits and Compensation

TCG Labs-Soleil provides a competitive benefits…