Principal Scientist, Peptide Formulation

Principal Scientist in Peptide Formulation (Discovery Pharm Sci)
** Position Description**:

The Discovery Pharmaceutical Sciences (DPS) group based in South San Francisco, CA is seeking a Principal Scientist with expertise in formulation development and candidate selection of peptides.

DPS is a multi-disciplinary research group that provides drug delivery, pre-formulation and formulation support for peptides, biologics and,small molecules at the development and drug discovery interface.  Our team is responsible for the characterization of pre-clinical drug candidates' physicochemical properties.  We aim to work with partner groups to select candidates with optimal development properties while balancing all other key therapeutic properties.  Our research also covers identification of preclinical formulations for pharmacology and toxicology studies and ideally for FIH across a variety of administration routes and modalities (biologics, small molecules, peptides, and oligonucleotides).In

this exciting role, you will focus on the characterization, early formulation development, develop ability  assessment and delivery approaches for various peptide modalities.  Goals include a) early formulation screening and develop ability assessment as well as b) recommendation of single candidate together with partner functions. Innovation in peptide formulation and drug delivery will be critical. You will serve as a team member and execute lab experiments yourself with minimal supervision.  

You will generate these key data sets and convey their meaning to the teams you work on and develop strategies to optimize molecules and their formulations.  Within DPS you will have the opportunity to contribute to departmental scientific initiatives as an individual contributor and as a technical lead to mentor junior scientists. You will also closely interact with other key functions required for the progression of clinical candidate selection including Medicinal Chemistry, Drug Metabolism and Pharmacokinetics, Nonclinical Drug Safety and Drug Product team.

The successful candidate will have expertise in characterizing physicochemical properties of peptide molecules such as oligomer state, fibrillation risk. A demonstrated track record of problem-solving skills and ability to drive innovation (as evidenced by publication, talks, or patents) is highly appreciated.
** Position Qualifications**:

Required

Experience and Skills:

* Successful candidates will have a PhD degree with a minimum of 6 years of relevant industrial experience in developing peptide formulations in preclinical or clinical stages. Excellent verbal and written communication skills are required. Strong leadership/interpersonal skills and motivation to work in a team environment with cross-functional interactions are essential.

Preferred

Experience and Skills:

* Candidates with experience in pre-clinical /clinical formulation development and physico-chemical characterization of peptides are preferred. Experience in candidate selection, and develop ability assessment is highly relevant. Additional experience in drug delivery technology is helpful.  
*
* Required Skills:

** Cell Culture Process Development, Cell Line Development, Clinical Development, Combination Products, Drug Delivery, Drug Design, Drug Development, Drug Formulations, Finite Element Analysis (FEA), Messenger RNA, Oligonucleotides, Peptides, Peptide Synthesis, Pharmaceutical Process Development, Pharmacodynamics, Pharmacokinetics, Pharmacology, Product Formulation, Protein Biochemistry, Protein Chemistry, Quality by Design, Scientific Research, Technology Transfer
** Preferred

Skills:

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