Senior Scientist - Experimental Protein Design Target Discovery

Senior Scientist Experimental Protein Design for Target Discovery What you will do

In this vital role you will build and lead high-throughput platforms for binder generation, translating computational protein designs into experimentally validated minibinders and antibodies across diverse pre-discovery targets. A key focus of this role is the production, experimental validation, and characterization of computationally designed de novo binders. You will play a central role in creating scalable binder libraries for multiplexed phenotypic screening, developing multispecific tool molecules to interrogate novel biology and providing tool reagents for early-stage target characterization.

By integrating computational design with rapid experimental validation, you will advance high-throughput binder discovery strategies and drive innovative approaches to probe emerging targets and accelerate early-stage therapeutic discovery.

• Translate computational protein designs into experimentally testable minibinders and antibodies across multiple targets in parallel.
• Lead high-throughput workflows for binder expression, purification, and characterization, including development of cellular assays for binder-target evaluation.
• Partner with molecular biology teams to establish construct generation and binder library production workflows, enabling both individual binder characterization and scalable pooled library screening.
• Develop strategies to format de novo binders into appropriate modalities (e.g., multispecifics) to enable testing of biological hypotheses.
• Analyze and interpret experimental data to guide iterative design-build-test cycles.

We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a highly motivated researcher with these qualifications.

• Doctorate degree PhD
• OR PharmD
• OR MD [and relevant post-doc experience on Protein Engineering]
• OR Masters degree and 3 years of Protein Engineering experience
• OR Bachelors degree and 5 years of Protein Engineering experience

• Ph.D. in Biochemistry, Protein Engineering, Bioengineering, Structural Biology, or a related field plus relevant postdoctoral experience.
• Demonstrated experience in the expression, purification, and biochemical or biophysical characterization of engineered proteins, such as antibodies, minibinders, or other designed scaffolds in a high-throughput or library-based manner.
  
  Experience with different expression hosts (cell-free expression,
  
  E. coli, and mammalian) is a plus.
• Experience in binder hit validation using flow cytometry and SPR, and in developing cellular-based assays for functional characterization.
• Experience working with designed binders or protein-protein interaction engineering, with working knowledge of protein structure-function relationships.
• Experience and interest in collaborating with computational protein design teams and translating in silico designs into experimentally testable reagents.
• Experience with automation platforms and high-throughput experimentation is a plus.
• Experience supporting phenotypic screening, receptor biology, or early target characterization is a plus.
• Strong organizational and communication skills, with the ability to work effectively in cross-functional discovery teams.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible…