Research Scientist

Singleton Bio is an early-stage therapeutics company using generative AI models of human tissue to discover therapeutic targets in immunological and inflammatory diseases. Our mission requires strategic thinking, nimbleness, and deep expertise in several areas including computational biology, immunobiology, in vitro and in vivo pharmacology. This new startup company is recruiting for talented, experienced, and passionate individuals who are looking to meaningfully contribute to the creation of new medicines.

Our Cell Interaction Foundation Model (CIFM) or “virtual tissue model” platform is a geometric graph neural network trained on spatial genomics data from millions of human cells. Built on more than a decade of virtual cell and tissue modeling research, the model learns the relationship between a cell’s expression state and its tissue microenvironment, and is used to simulate how tissue responds to perturbations at scale.

Singleton is a fast-paced, dynamic environment where teammates will have broad exposure to the intersection of artificial intelligence-driven tissue models and drug development. We are rapidly building the Company and are looking for scientists to join us on this mission. Singleton Bio, located in South San Francisco, CA, is seeking an exceptional individual to join our team as a Research Scientist.

Singleton Bio is an early-stage therapeutics company using generative AI models of human tissue to discover therapeutic targets in immunological and inflammatory diseases. Our mission requires strategic thinking, nimbleness, and deep expertise in several areas including computational biology, immunobiology, in vitro and in vivo pharmacology. This new startup company is recruiting for talented, experienced, and passionate individuals who are looking to meaningfully contribute to the creation of new medicines.

Our Cell Interaction Foundation Model (CIFM) or “virtual tissue model” platform is a geometric graph neural network trained on spatial genomics data from millions of human cells. Built on more than a decade of virtual cell and tissue modeling research, the model learns the relationship between a cell’s expression state and its tissue microenvironment, and is used to simulate how tissue responds to perturbations at scale.

Singleton is a fast-paced, dynamic environment where teammates will have broad exposure to the intersection of artificial intelligence-driven tissue models and drug development. We are rapidly building the Company and are looking for scientists to join us on this mission. Singleton Bio, located in South San Francisco, CA, is seeking an exceptional individual to join our team as a Research Scientist.

We are seeking a hands-on Research Scientist to help build out Singleton Bio's lab-based capabilities, including cell- and tissue-based assays to experimentally validate virtual tissue model outputs. These assays involve genetic and pharmacologic perturbation studies with mechanistic and phenotypic readouts that feed back into the model. Singleton Bio's focus is in autoimmune and chronic inflammatory disease, where much of the relevant biology plays out between immune cells and the stromal and parenchymal cells around them.

This is a bench-heavy role for someone who is energized by novel targets and biology, and who is comfortable working in both immortalized lines and primary cells, including primary immune cells.

• Partner with the computational team to translate virtual tissue model outputs — cell type–specific expression, ligand–receptor inference, disease-associated microenvironments — into concrete, testable in vitro hypotheses.
• Select, qualify, and run cell and tissue models to validate targets by…