Senior Scientist​/Principal Scientist, Protein Sciences: Analytical & Biophysical Characterizations

Soleil is seeking an expert, hands-on scientist to lead our analytical and biophysical characterization efforts within the Protein Sciences group of the Technology team. In this role, you will design, develop, validate, and execute comprehensive develop ability assessments and analytical characterizations for our biologics portfolio (antibodies, multi-specifics, fusion proteins). You will be the go-to expert for complex analytical challenges, drive technical strategy across programs, and work collaboratively with research and development teams to generate critical data that inform candidate selection and progression.

This is a highly technical, hands-on position where you will spend time at the bench while contributing strategic leadership on analytical and develop ability matters.

• Design, develop, validate, and execute analytical and biophysical methods (with emphasis on LC-MS, chromatography, thermal/structural assays, and immunogenicity assessments) for diverse protein and antibody formats
• Establish robust, fit-for-purpose assays that characterize therapeutic biologics throughout the preclinical pipeline
• Execute experiments with precision, conduct detailed observations, analyze and interpret data rigorously, and deliver results in a timely, concise manner to program teams

• Prepare and lead comprehensive develop ability assessments packages for biologic candidates, evaluating stability, solubility, aggregation, post-translational modifications, manufacturability, immunogenicity potential, and key risk factors
• Serve as technical lead for due diligence and business development contexts: evaluate external analytical data, review technical packages, identify risk, and advise senior decision-makers on analytical feasibility and candidacy
• Define analytical strategy across the portfolio in collaboration with research, CMC, and program teams; ensure alignment with formulation and process development

• Serve as SME for complex analytical and characterization challenges; provide expert guidance to cross-functional teams on technical issues and method refinements
• Evaluate emerging analytical technologies for feasibility and performance; guide adoption to enhance throughput, sensitivity, and risk mitigation
• Mentor junior scientists and collaborate with peers on scientific approaches and best practices

• Lead a focused analytical team (1 direct report) while managing CRO partnerships for specialized assay work, validation, and tech transfer.
• Play a key analytical role in drug candidate selection decisions across the portfolio; advise senior leadership on analytical feasibility and develop ability risk

• Prepare precise technical summaries, protocols, analytical packages, and maintain rigorous documentation standards suitable for regulatory submissions and internal reporting
• Contribute to program team discussions as a functional technical lead, effectively communicate across line-functions

This is a full-time, lab-based position combining hands-on technical execution with leadership and strategic responsibilities.

• Ph.D. or equivalent in a related discipline (e.g. molecular biology, biochemistry, biophysics, analytical chemistry) with 5 years’ experience in protein and antibody characterization and develop ability in an industry setting, preferably startup or biotechnology companies

• Expert in biophysical and analytical techniques including but not limited to HPLC, CE, SPR, DSF, DSC, SEC-MALS, LC-MS, and immunogenicity assays
• Solid, hands-on understanding of protein analytical principles, methodologies, and PTMs characterization
• Extensive, hands-on experience in develop ability studies for antibody therapeutics, including monoclonal, bispecific, and multi-specific antibodies, fusion proteins, and antibody-drug conjugates
• Deep understanding of attributes of protein therapeutic drug candidates and biologics drug discovery process (hit-to-lead, lead optimization, candidate selection)
• Experience with protein purification, membrane proteins, and/or multi-specific antibody formats is highly…