Senior Scientist, Molecular Interactions

• Scientific Leadership and Project Support:
  Design, execute, troubleshoot, and interpret molecular interaction studies that guide program direction and molecule selection.
• Generate high-quality data using molecular interaction and cell based assays, including binding, affinity, kinetics, avidity, epitope binning, competition, receptor occupancy, internalization, signaling, and functional potency, to support optimization and risk assessment.
• Partner with multidisciplinary teams to define assay strategies, prioritize samples, deliver results on schedule, document methods and conclusions, and clearly communicate findings, risks, and recommendations.
• Platform Development and Innovation:
  Apply molecular interaction platforms, including surface plasmon resonance, Carterra, biolayer interferometry, and flow cytometry, to support biologics discovery.
• Develop and optimize assay formats, automation, data analysis, and visualization workflows to improve throughput, robustness, data quality, and turnaround time.
• Evaluate and integrate new technologies, resolve platform issues, and establish reproducible protocols and workflows that enable efficient knowledge transfer.
• Scientific Excellence and Mentorship:
  Apply rigorous experimental design, appropriate controls, quantitative data interpretation, and effective troubleshooting practices.
• Work independently on complex studies while collaborating effectively in a multidisciplinary research environment.
• Maintain a current understanding of advances in molecular interactions, protein characterization, antibody engineering, and biologics discovery.
• Contribute to scientific presentations, publications, intellectual property, and the development of junior scientists while following all applicable laboratory, documentation, data integrity, and safety requirements.

• Education:
  
  Bachelor's (with 7+ years) or Master's (with 4+ years) in a biological science field and relevant industry experience. Ph.D. in a biological science field and relevant experience.
• Required
  
  Experience and Skills:
  
  Proven ability to independently design, execute, and interpret complex experiments, including kinetic and affinity studies of protein interactions.
• Demonstrated expertise in biomolecular interactions, protein characterization, and quantitative assay development, with hands on experience designing, optimizing, and interpreting cell based binding or functional assays.
• Hands on experience with one or more interaction analysis platforms, such as surface plasmon resonance, Carterra, Biacore, biolayer interferometry, KinExA, or related technologies.
• Excellent problem solving, critical thinking, troubleshooting, and organizational skills, with a demonstrated ability to deliver high-quality results within defined timelines.
• Strong written and verbal communication skills, with a demonstrated ability to work effectively in a collaborative, team-oriented environment.
• Preferred
  
  Experience and Skills:
  
  Postdoctoral or industry experience supporting therapeutic antibody, multispecific, or other biologics discovery programs.
• Experience with epitope binning, competition assays, receptor pharmacology, develop ability assessment, and cell-based characterization of biologics, including flow cytometry, receptor binding or occupancy, internalization, signaling, reporter gene, proliferation, or other functional potency assays.
• Knowledge of antibody engineering, Fc biology, and relationships among protein structure, molecular interactions, and biological function.
• Familiarity with automation, high throughput workflows, and modern data analysis and visualization tools.

The primary location for this posting is: USA
- California
- South San Francisco (Grand Ave) Where…