Associate Scientist, Late-Stage Purification Process Development

Associate Scientist, Late-Stage Purification Process Development page is loaded## Associate Scientist, Late-Stage Purification Process Development locations:
South San Francisco time type:
Full time posted on:
Posted Todayjob requisition :
R-1440

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

We are seeking to hire an Associate Scientist to join our Purification Process Development team. The successful candidate will be responsible for supporting late-stage downstream process development activities for our large molecule pipeline.
** Key Accountabilities/Core

Job Responsibilities **:
* Support purification process characterization, validation, PPQ and BLA-enabling activities.
* Monitor process performance, trend data, and coordinate sample handling from GMP manufacturing campaigns.
* Extract and organize data for report and submission authoring and contribute to statistical analysis.
* Support tech transfer for and GMP campaign readiness.
* Execute lab-scale chromatography and filtration studies to inform late-stage data packages.
* Execute in-process testing using ELISA, HPLC, UV and SDS-Page based analytics
* Summarize key experimental data and document all experiments in an electronic lab notebook in a timely manner.
* Collaborate closely with colleagues in CMC, Discovery and other functions to achieve project goals.
** Requirements
* ** BS/MS in Biology, Biochemistry, Chemical Engineering or related scientific discipline with 3+ years of industry experience
* Experience in protein characterization, design of experiments and analytics
* Experience monitoring downstream GMP and/or pilot production unit operations
* Hands-on experience with AKTA protein purification systems, lab-scale TFF systems and antibody characterization methods including: HPLC, LC/MS, SDS‐PAGE, DLS and other biophysical techniques
* Excellent critical thinking, scientific problem-solving and communication skills
* Prior experience in a late-stage process development setting is preferred

Salary Range: $ to $ .  Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at  compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.“Life

at Denali” is a living reflection of our values: trust, unity, grit and growth. These are not just words we share—they shape how we show up, collaborate and push boundaries together. From the lab to the community, across functions and milestones, our culture thrives on shared purpose and relentless pursuit.
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