Senior Clinical Trial Manager

Marea Therapeutics is a clinical-stage biotechnology company based in South San Francisco with a growing pipeline of first-in-class therapies to address genetically validated cardioendocrine disease targets. Our therapies have the potential to serve as transformative treatment options for significant patient populations living with cardioendocrine diseases.

The company’s lead program, MAR
001, is being developed for the treatment of severe hypertriglyceridemia (sHTG), a condition characterized by very high triglyceride levels and elevated risk of acute pancreatitis. Preclinical models with MAR
001 demonstrated reduction in triglycerides, remnant cholesterol and ectopic fat, and improved insulin sensitivity. MAR
001 has demonstrated strong and a differentiated profile in patients and is approaching Phase 3 development. Our second clinical asset, MAR
002, is a monoclonal antibody targeting excess growth hormone produced by the pituitary gland in the rare hormonal disorder, acromegaly. MAR
002 has potential to become best-in-disease and is quickly progressing into Phase 2/3 clinical development. We also have a third asset that is swiftly advancing through research discovery, with DC nomination expected this year.

At Marea, we believe in the power of collaboration and the importance of leading by example. We are a tight-knit team that values the contributions of every member, from interns to senior leaders. Our environment is dynamic, with each day presenting new challenges and opportunities for growth. Every role is “Hands-On”, and the successful candidate will be able to work alongside team members, regardless of level, to understand challenges and drive results.

Reporting to the Director of Clinical Operations, the Senior Clinical Trial Manager (Sr. CTM) will lead the day-to-day execution and management of clinical trials, ensuring studies are conducted efficiently, on time, within budget, and in compliance with GCP and regulatory requirements.

This role is a hands-on operational leader at the study level, responsible for driving execution across study start-up, enrollment, maintenance, and close-out activities. The Sr. CTM will work closely with cross-functional partners and oversee CROs and vendors to ensure high-quality delivery of clinical trial milestones. There may be the opportunity to mentor junior members of the Marea team.

In this role, the Sr. CTM will be a key clinical operations leader supporting our MAR
002 program, specifically driving the execution of a Ph. 2/3 study to support product registration. MAR
002 is a first-in-class- and potentially a best in disease anti-growth hormone receptor antibody monoclonal antibody indicated for growth hormone control (IGF-1 normalization) in acromegaly.

This is a full-time, South San Francisco-based position with the expectation of working on-site at least three days per week.

• Support program lead with setting and timely executing the development strategies for the clinical studies.
• Responsible for the strategic and operational oversight, management, execution, and delivery of the clinical studies for MAR
  002 and related clinical program activities.
• Lead the Study Management Team (SMT) for assigned clinical study.
• Resolve and/or escape issues raised by the clinical operations team or the SMT.
• Ensure consistency between studies for assigned clinical program.

• Support vendor selection, including request for proposals, leading bid defense meetings, critical review of contracts and negotiation of work orders.
• Oversee CROs and other selected vendors on a product level including setting and monitoring key performance indicators and ensuring successful execution of the clinical program/studies and…