Senior ML Research Engineer — Frontier Drug Discovery

Calico Life Sciences in South San Francisco is seeking Machine Learning Research Engineers to join our rapidly growing ML team. You will help establish the engineering culture for frontier ML research in drug discovery and translate research prototypes into scalable, production‑ready systems.

This high‑agency role requires strong Python and JAX or PyTorch expertise, hands‑on experience with transformers, diffusion networks or GNNs, and a willingness to work onsite at least four days per week.

We invite applications for the Senior ML Research Engineer — Frontier Drug Discovery position located in South San Francisco, CA, United States.

Join Calico Life Sciences and contribute to our ongoing work.

Take a moment to read everything above and see whether this role is right for you.

This posting is for the Senior ML Research Engineer — Frontier Drug Discovery role at Calico Life Sciences, based in South San Francisco, CA, United States.