Experienced In Vitro Toxicology Scientist

BAT is evolving at pace into a global multi-category business. Our purpose is to create A Better Tomorrow™ by Building a Smokeless World.

To achieve our ambition, we are looking for colleagues who are ready to join us on this journey! Tomorrow can’t wait, let’s shape it together.

To provide technical direction, execution and delivery for the development and application of in vitro Regulatory (Genetic) Toxicology to support the Preclinical Science programme.

To be accountable for supporting the development of tools, knowledge and data in preclinical sciences across all BAT categories

Complete pre-clinical capabilities, inclusive of in silico, in vitro and in vivo models, for predominantly regulatory submissions, inclusive of but not limited to FDA authorizations and approvals

The role will be accountable for driving the tools, knowledge and data in preclinical sciences across all BAT categories.

The primary purpose of preclinical data is to satisfy BATs’ duty of care by substantiating consumer product safety, meeting regulatory obligations and providing scientific substantiation of health-related claims such as reduced risk versus cigarettes.

Providing reliable, innovative, fit for purpose in vitro Regulatory Toxicology data to support BAT’s New Categories product innovation lifecycle and THR ambition

Supporting Quality Growth with in vitro Regulatory Toxicology data to enable foundational product understanding, product stewardship and regulatory submission

Supporting Sustainable Future and THR with innovative in vitro Regulatory Toxicology data, enabling regulatory engagement, scientific communications and collaborations

• Application of expert knowledge in the development and application of in vitro Regulatory (Genetic) Toxicology to achieve business unit goals
• To input into the technical application of the Regulatory Toxicology team to develop, deliver and ensure fit-for-purpose in-house testing capabilities and defined requirements to support Quality Growth
  -product innovation and PLM, and Sustainable Future- THR sciences and regulatory engagement
• Initiator or lead representative in interactions with internal partners and cross-functional teams (eg across Preclinical, Advanced Analytical, Toxicology, Clinical, Portfolio Management, QA)
• Initiator or lead representative in interactions with 3rd party external technical partners
• Ensure that data generated is timely, fit for purpose and meeting the appropriate quality requirements (data standards, RDRT) and business needs, harnessing approaches aligned to the digital transformation roadmap
• Maintain clear ways of working and adherence to key processes, providing clear technical leadership, maintaining a culture of continuous improvement
• Author, deliver and peer-review of R&S reports, internal and external publications and presentations.
• Understands and accountable for the Regulatory Toxicology team’s compliance to HTA and responsibilities under the EH&S policy
• Monitor the competitor landscape in the field of preclinical science and in vitro Regulatory Toxicology
• Application of project management and planning while completing tasks in accordance with BAT R&D business strategy and the code of business conduct

• Demonstrated experience and knowledge of in vitro Regulatory Toxicology to enable the in-house development of Neutral Red, Ames and in vitro micronucleus testing capabilities
• Proven track record in the application of in vitro approaches in the preclinical field to bridge to clinical endpoints and human health effects
• Knowledge of applying bioinformatics tools to process and assess biological data, and meeting appropriate data quality standards
• Experience in the application of standard processes in preclinical approaches and knowledge of associated regulatory guidelines such as OECD, ECVAM, ICCVAM and covering best technical practice in…