Senior Scientist - Downstream Analytics

Position: Senior Scientist - Downstream Analytics (Permanent)
Location: Portswood

Senior Scientist – Downstream Analytics (Large Molecules)

Biotech | HPLC | Bioprocessing | Southampton | Up to £50,000 + Benefits

We’re partnering with an innovative scientific organisation to recruit a Senior Scientist with strong experience in downstream analytical processes, including HPLC and bioprocessing techniques, to join a high-performing team based in Southampton. This hands-on role offers the chance to support the development of modified nucleic acids and peptides, drive analytical method development, and contribute to the advancement of large molecule therapeutics in a collaborative, fast-paced environment.

About the Role

You’ll take the lead on analytical workflows for nucleic acids, peptides, and antibodies, ensuring high standards of quality, compliance, and scientific rigour. The role will include method development, instrument maintenance, and cross-functional collaboration across R&D and production teams.

This position is ideal for a scientist who enjoys working across disciplines, mentoring junior colleagues, and staying at the forefront of analytical innovation.

Key Responsibilities

Lead downstream analytical workflows using HPLC, UPLC, PAGE, flash chromatography, and related techniques

Contribute to the purification and characterisation of large molecules, such as peptides and antibodies

Support method development and continuous improvement in analytical approaches

Collaborate with chemistry and production teams to support small molecule and oligonucleotide preparation

Maintain, calibrate, and optimise analytical instrumentation in line with ISO and internal quality systems

Mentor and support Associate Scientists and Lab Technicians

Ensure accurate documentation and maintain data integrity across workflows

Promote and uphold Health, Safety, and Environmental (HSE) standards

Manage stock levels of analytical reagents and consumables

Stay up to date on emerging trends in bioprocessing and analytical technologies

About You

We’re looking for a motivated and collaborative scientist with a solid grounding in downstream analytical techniques and a passion for quality science.

You’ll ideally have:

A PhD (or equivalent experience) in Analytical Chemistry, Biochemistry, or a related field

Strong hands-on experience in HPLC and bioprocessing within a biotechnology, pharmaceutical, or life sciences environment

Knowledge of purification and characterisation methods for peptides, antibodies, or similar large molecules

Experience with TFF or tangential flow filtration (advantageous)

Familiarity with ISO or GMP-regulated environments

Ability to lead technical projects and support team development

Strong communication and problem-solving skills

A flexible, proactive mindset with strong attention to detail

Salary & Benefits

Salary:
Up to £50,000 depending on experience

Location:

On-site in Southampton

Holidays: 25 days annual leave + 8 bank holidays

Pension: 6% employer contribution

Life Assurance: 4x salary

Additional Benefits Include:

Flexible working hours

Long service awards and recognition scheme

Employee Assistance Programme with 24/7 remote GP access

Annual flu vaccinations

Cycle to work scheme and gym discounts

Discounts and savings platform

Professional membership reimbursement

Referral incentives

Social events and volunteering days