Senior Scientist - Downstream Processing

Senior Scientist - Downstream Processing

Biotage Southampton, England, United Kingdom

Join our high-performing Oligonucleotide Production team in Southampton—a vibrant coastal city offering the perfect balance of professional opportunity and quality of life, with excellent transport links.

We are seeking a Senior Scientist with deep expertise in downstream processing modalities including oligonucleotides/Peptides to lead analytical strategy and contribute to the development and production of high‑quality modified Oligonucleotides.

• Lead and oversee downstream workflows, supporting purification, analysis and characterisation of oligonucleotides including HPLC, SDS‑PAGE, TFF and UPLC‑MS
• Stay abreast of emerging technologies and methodologies in nucleic acid chemistry
• Drive method development and troubleshooting with purification techniques
• Collaborate cross‑functionally across the organisation
• Coach and mentor junior team members

• Ph.D. in Chemistry and/or related discipline
• Proven hands‑on experience working with oligonucleotides/peptides is highly desirable within academia or industry (small‑molecule experience will also be considered)
• Experience of UF/DF and TFF is highly desirable
• Strong background in purification and downstream processing techniques – HPLC, UPLC‑MS, SDS‑PAGE
• Experience working in ISO/GMP regulated environments is highly desirable
• Self‑starter with the ability to lead projects which require troubleshooting and problem solving
• Detail‑oriented, strong communicator who can work under pressure in a fast‑changing environment

• 25 days annual leave plus 8 paid bank holidays
• Contributory pension scheme (6% employer contribution)
• Life Assurance (x4 salary)
• Long service awards
• Reward and recognition scheme
• Employer Assistance Programme with 24/7 remote GP service
• Annual flu jabs
• Cycle to work scheme
• Corporate discount on gym membership
• Savings and discounts
• Reimbursement of professional membership fees
• Referral incentives
• Social events

Biotage is a global supplier and solutions partner to a wide range of customers within drug discovery and development and analytical testing. With strong expertise in separation and purification technologies, and a focus on leveraging intelligent workflow solutions, we aim to efficiently support the advancement and protection of human health. Learn more at

Mid‑Senior level

Full‑time

Research